摘要
为研究强力方 (黄芪、熟地黄、仙灵脾、党参、白术、升麻、葛根、锁阳、甜苁蓉、制首乌、炙甘草 )对实验性自身免疫性重症肌无力 (EAMG)细胞因子含量的影响 ,采用乙酰胆碱受体 (AchR)与福氏佐剂乳化多次免疫SD大鼠复制EAMG模型 ,以强的松作为对照 ,观察该方对模型大鼠体重、活动情况、负荷游泳时间以及乙酰胆碱受体抗体 (AchR Ab)滴度、肌电图、血清IFN γ和TNF α含量等的影响。结果表明强力方对EAMG有与强的松相近的治疗效果 ,可使AchR Ab滴度降低 ,肌电图递减幅度好转 ,血清IFN γ、TNF α含量减少。提示强力方治疗EAMG的部分机制是调节免疫功能 ,影响细胞因子IFN γ、TNF
To investigate the influence of “Powerful Prescription”on cytokine of experimental autoimmune myasthenia gravis(EAMG),EAMG SD rats were modeled by using AchR and forl adjuvant,which were respectively treated by“Powerful Prescription”and prednisone(as control).The ratsweight,activity,loading swimming time,AchR Ab titer,electromyogram,serum IFN α and TNF α were observed.Results showed that“Powerful Prescription”had similar effect with prednisone,reducing AchR Ab titer,improving electromyogram,lowering IFN α and TNF α.The results revealed that some of the mechanisms of“Powerful Prescription”in treating EAMG were regulating the immune function,influencing the IFN α and TNF α expresses.
出处
《上海中医药杂志》
北大核心
2000年第10期40-43,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市医学领先专业特色专科基金!(96Ⅱ00 3)
关键词
强力方
重症肌无力
自身免疫性
细胞因子
Powerful Prescription”
myasthenia gravis(MG)
experimental autoimmune myasthenia gravis(EAMG)cytokine
experimental research
