摘要
目的探讨白介素-8(IL-8)与肿瘤坏死因子-α(TNF-α)在COPD急性发作期(AECOPD)的表达水平变化及其与预后的关系。方法选取本院收治的36例AECOPD患者(观察组)与同期进行健康体检的36例健康者作为研究对象,检测两组研究对象的IL-8与TNF-α的基础水平。同时比较观察组刚入院时与治疗一个月后IL-8与TNF-α的水平。结果观察组患者入院时IL-8平均水平为(0.488±0.221)μg/L,TNF-α平均水平为(3.354±0.282)μg/L,与对照组相比,差异有统计学意义(P<0.05)。观察组患者经抗感染及综合治疗一个月后IL-8水平为(0.442±0.230)μg/L,与治疗前相比,差异无统计学意义(P>0.05)。TNF-α水平为(2.881±0.289)μg/L,与治疗前相比,TNF-α水平有显著性下降,差异有统计学意义(P<0.05)。结论IL-8、TNF-α共同参与了COPD复杂的炎症反应,在COPD急性发作期有显著升高,对临床诊断急性COPD有指导意义。同时,TNF-α水平可随病情好转而下降,可作为判断COPD预后的指标。
Objective To investigate the changes of interleukin-8 and tumor necrosis factor-ct of COPD patients at acute exacer- bation stage and to analyze their prognosis. Methods 36 AECOPD patients in our hospital were selected as the observation group, and 36 healthy people were taken as the control group. The levels of IL-8 and TNF-a were measured and compared before and 1 month after the treatment between the two groups. Results The levels of IL-8 and TNF-a was obviously higher in the observation group than in the con- trol group. 1 month after the treatment, the level of IL-8 was still obviously higher in the observation group than in the control group （P 〈 0. 05 ）, but there was no significant difference of TNF-a level between the two groups （P 〉 0.05 ）. Conclusion IL-8 and TNF-a both participate in complex inflammatory response of COPD patients. TNF-a involves in the entire inflammatory process as an early inflammatory cytokines, and IL-8 is produced by TNF-ct and other early inflammatory eytokines. These factors interact with each other.
出处
《临床肺科杂志》
2013年第10期1753-1755,共3页
Journal of Clinical Pulmonary Medicine
