摘要
2-甲基苯并咪唑是重要的医药及染料中间体。以邻苯二胺与乙酸为原料,微波促进001 H型树脂催化合成了2-甲基苯并咪唑。通过单因素实验考察了微波功率、反应时间、原料质量配比、树脂用量、树脂重复使用对2-甲基苯并咪唑合成收率的影响。结果发现,当微波功率为455 W、树脂用量0.5 g、反应时间为30 min、邻苯二胺用量1.08 g、乙酸用量3.24 g时收率最高,可达84.8%。树脂重复使用可行性的研究表明,树脂重复使用两次后,2-甲基苯并咪唑收率从84.8%下降66.7%。结果表明相比于2-甲基苯并咪唑的传统合成方法,具有产率高、工艺操作简单、环境污染效应小等优点,不足之处在于催化剂重复使用性较差,需做进一步的研究工作。
2-methyl benzimidazole,an important medicine and dye intermediate,was synthesized under microwave irradiation using diaminobenzene and acetic acid as raw materials and catalyzed by 001 H resin.The effects of microwave power,reaction time,mass ratio of raw materials,dose of resin and the reusage of 001 H resin on the yield of 2-methyl benzimidazole were investigated by single factor experiment.The results showed that the highest yield reached 84.8% under the optimum reaction conditions：microwave power 455 W,001 H resin 0.5 g,reaction time 30 min,diaminobenzene 1.08 g,and acetic acid 3.24 g.The study on the reusage of 001 H resin indicated that the yield of 2-methyl benzimidazole decreased from 84.8% to 66.7% after 001 H resin was used for three times.Compared with the traditional synthesis methods of 2-methyl benzimidazole,the method in this work has many advantages,such as higher yield,simpler process and less environmental pollution,but poor reusage of 001 H resin,which needs further research.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2013年第5期1140-1144,共5页
Chemical Industry and Engineering Progress
基金
住房和城乡建设部2011年科学技术计划(2011-K4-2)
苏州市应用基础研究(SYG201123)项目
关键词
微波
阳离子交换树脂
2-甲苯并咪唑
合成
microwave
cation exchange resin
2-methyl benzimidazole
synthesis
