摘要
以邻苯二胺和乙酸为原料,在盐酸催化下,合成了2-甲基苯并咪唑,收率高达95.6%。考察了反应物配比、盐酸用量、反应时间和反应温度对收率的影响,结果表明,最佳反应条件为:邻苯二胺:乙酸=1:1.4,浓度为4mol/L的盐酸用量为邻苯二胺的2.2倍,反应温度100℃,反应时间1h,自然冷却1h。
2 methylbenzimidazole was prepared from o phenylenediamine and acetic acid, catalyzed under aqueous hydrochloride, the yield was 95.6%. The reaction conditions including molar ratio, reaction ternperature, and reaction time were investigated. The optimal conditions were as following, ratio of o phenylenediamine and acetic acid was 1 ： 1.4, the dosage of aqueous hydrochloride was 2.4, the reaction temperaturewas 98 100℃, the reaction time was 1.5h.
作者
张宏
王艳戎
罗兰
Zhang Hong;Wang Yanrong;Luo Lan(Sichuan Vocational College Of Chemical Tecknology,Luzkou 646005,Sichuan,China;Luzhou Vocational＆ Tecknical College,Luzhou 646005,Sichuan,China)
出处
《四川化工》
CAS
2018年第4期4-5,共2页
Sichuan Chemical Industry
关键词
2-甲基苯并咪唑
邻苯二胺
环合
2 -methylbenzimidazole
o phenylenediamine
cyclation
