摘要
目的 研究大鼠胆汁中 β 榄香烯的代谢产物。 方法 采用质谱、核磁共振、红外、紫外分析法对ivβ 榄香烯后大鼠胆汁样品进行分析。结果 确定了一个代谢产物的结构为 1 甲基 1 乙烯基 2 异丙烯基 4 异丙烯醛基环己烷。结论 β 榄香烯在体内存在生物转化过程。
AIM To study the metabolite of β elemene in the bile of rat. METHODS After iv 100 mg·kg -1 β elemene, the metabolite in rat bile was extracted by ether. Mass spectrometry, nuclear magnetic resonance, infrared spectrometry and ultraviolet spectrometry were used to analyze the metabolite of iv β elemene in rat bile. RESULTS It was confirmed by nuclear magnetic resonance that the methyl of No.11 carbon connecting with No.10 carbon of a metabolite in rat bile was oxidized to be aldehyde. The molecular weight of the metabolite was 218 which detected by mass spectrometry. Infrared spectrometry and ultraviolet spectrometry proved that the aldehyde existed in the metabolite. The structure of the metabolite in bile of rat was identified, that was 1 methyl 1 ethenyl 2 isopropenyl 4 isopropenyl aldehydohexamethylene. CONCLUSION The biotransformation of β elemene exists in vivo .
出处
《药学学报》
CAS
CSCD
北大核心
2000年第11期829-831,共3页
Acta Pharmaceutica Sinica
