摘要
目的 研究β 榄香烯自大鼠呼吸道排泄规律。方法 采用自制的呼吸道药物收集装置,大鼠iv或ipβ 榄香烯 75mg·kg-1后,于不同时间点收集呼出气体,用气相色谱法测定药物浓度。结果 大鼠iv或ipβ 榄香烯 7.5mg·kg-1. 6h后的累积排出量分别为给药剂量的 1 .41%和 0.1%。结论 原形药可经呼吸道排出,但不是β 榄香烯在大鼠体内消除的主要方式。
Aim To investigate the excretion of β-elemene from the respiratory tracts in male Spraque-Dawley rats. Methods After a single administration of β-elemene to rats at the dosage of 75 mg·kg-1 (iv or ip), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography. Results A minor amount of unchanged β-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively. Conclusion The results demonstrated that unchanged β-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.
出处
《药学学报》
CAS
CSCD
北大核心
2005年第1期54-56,共3页
Acta Pharmaceutica Sinica
关键词
Β-榄香烯
气相色谱
呼吸道排泄
β-elemene
gas chromatography
respiratory excretion
