摘要
目的:探讨外周血T细胞亚群检测在恶性肿瘤中的应用及临床意义。方法:选取我院收治的149例恶性肿瘤患者(恶性肿瘤组)及门诊体检正常人150(对照组),以流式细胞术测定两组外周血T细胞亚群(CD3+细胞、CD4+细胞、CD8+细胞、CD4+/CD8+细胞)水平。结果:恶性肿瘤组CD3+细胞、CD4+细胞、CD4+/CD8+细胞较对照组下降,CD8+细胞较对照组升高,两组比较差异具有统计学意义(P<0.05);恶性肿瘤患者T细胞亚群与对照组进行比较,肺癌、胃癌、肝癌、恶性淋巴瘤、结直肠癌、乳腺癌患者D3+细胞、CD4+细胞、CD4+/CD8+细胞均较对照组下降,CD8+细胞较对照组升高,比较差异具有统计学意义(P<0.05);CD3+细胞、CD4+细胞、CD8+细胞、CD4+/CD8+细胞在不同性别及年龄之间比较差异无统计学意义(P>0.05)。结论:恶性肿瘤患者存在免疫抑制情况,对恶性肿瘤患者检测外周血T细胞亚群有助于了解患者机体免疫功能状况,为患者治疗及预后的判断提供参考。
Objective ： To investigate value of peripheral blood T cell subgroup detection in malignant tumor and its clinical significance.Methods ： Selected 149cases of patients with malignant tumors（malignant group） admitted to our hospital and 150healthy volunteers in outpatient department（control group）.Peripheral blood T cell subsets（CD3 ＋ cells and CD4 ＋ cells,CD8 ＋ cells and CD4 ＋ / CD8 ＋ cells） were detected with flow cytometry measurement.Results ： In the malignant tumor group,CD3 ＋ cells,CD4 ＋ cells and CD4 ＋ / CD8 ＋ cells were decreased and lower than that of the control group,while CD8 ＋ cells were higher（P0.05）.For patients with lung cancer,gastric cancer,liver cancer,malignant lymphoma,colorectal cancer,breast cancer,CD3 ＋ cells,CD4 ＋ cells and CD4 ＋ / CD8 ＋ cells were decreased and were lower than that of the control group,but CD8 ＋ cells were higher than that of the control group（P 0.05）;CD3 ＋ cells,CD4 ＋ cells,CD8 ＋ cells and CD4 ＋ / CD8 ＋ cells were not significant different among different age groups or between different genders（P0.05）.Conclusion ： In malignant tumor patients,immunosuppression exist,detection of peripheral blood T cell subsets in these patients contributes to an understanding of the body＇s immune function and provide reference for treatment and prognosis of patient.
出处
《海南医学院学报》
CAS
2013年第10期1390-1392,1395,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210815)~~
