摘要
目的探讨高血压合并代谢综合征与颈动脉粥样硬化的相关性。方法选择高血压合并代谢综合征患者52例,单纯高血压病患者42例。全部患者进行颈部动脉血管B超检测,收集临床资料,比较两组颈动脉粥样硬化发生情况。结果观察组与对照组相比较,体重指数(BMI)、空腹血糖(FPG)、餐后2h血糖(2hPG)、胰岛素抵抗指数(HOMA-IR)和总胆固醇(TC)显著升高(P<0.05);高密度脂蛋白(HDL-C)在观察组显著低于对照组(P<0.05);颈总动脉内中膜厚度和颈内动脉内中膜厚度明显增厚(P<0.05);观察组颈总动脉粥样硬化发生率84.0%,高于对照组61.9%(P<0.05);颈总动脉左右侧血管内径及阻力指数均明显增加(P<0.05);两组间收缩期血流峰值无统计学意义。结论高血压合并代谢综合征患者更容易发生颈动脉粥样硬化,代谢综合征可能促进高血压患者颈动脉粥样硬化的形成。
Objective To study relation between hypertension complicating with metabolic syndrome and carotid artery atherosele-rosis. Methods Fifty- two patients （pts） with hypertension complicating with metabolic syndrome were as observation group,and 42 pts with isolated high blood pressure were as control group. The carotid B ultrasonic was detected and clinical data were collected in all pts. Results Body mass index （BMI） ,fasting plasma glucose （FPG） ,2 h plasma glucose （2 hPG） ,homeostasis model assessment for insulin resistance （HOMA- IR） and total cholesterol （TC） in observation group were significant higher than that in control group （P〈0.05）. The high - density lipoprotein- cholesterol （HDL - C） in observation group was significantly lower than that in control group（P〈0.05）. The carotid intima - media thickness and internal carotid intima - media thickness in observation group were obvious thickening（P〈0.05）. The carotid atherosclerosis incidence in observation group was 84.0 %, which higher than that in control group （61.9% ,P〈0.05）. The common carotid artery diameter and resistance index were significantly increased（P〈0.05）. There was no statistically difference in peak systolic blood flow between two groups （P〉0.05）. Conclusion Hypertension with metabolic syn drome could easily cause carotid artery atherosclerosis. Metabolic syndrome might promote the formation of carotid artery atherosclerosis.
出处
《中西医结合心脑血管病杂志》
2013年第3期272-273,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
高血压
代谢综合征
颈动脉粥样硬化
hypertension
metabolic syndrome
carotid atheroselerosis
