摘要
目的:观察中药复方稳消方对颈动脉粥样硬化(CAS)斑块患者血浆纤维蛋白原(FIB)、D-二聚体和血黏度的影响。方法:将72例CAS斑块患者随机分为治疗组和对照组,各36例;两组均维持原基础疾病治疗方案,治疗组同时内服稳消方,疗程6个月。检测两组治疗前后FIB、D-二聚体和血黏度等指标变化情况。结果:治疗后,治疗组FIB、D-二聚体水平低于对照组(P<0.05)。治疗后,治疗组全血黏度(中切)、血浆黏度和全血低切还原黏度较治疗前降低(P<0.05,P<0.01),且治疗组血黏度各项指标均明显优于对照组(P<0.01)。结论:稳消方可降低FIB和D-二聚体水平、改善血黏度以治疗CAS斑块。
Objective： To study the effects of ＂Wenxiao Decoction ＂on plasma fibrinogen（ FIB）,D-Dimer and blood viscosity in patients with carotid atherosclerotic（ CAS） plaque. Methods： Seventy-two patients with CAS plaque were randomized into the control group and the treatment group,36 cases in each group. Both groups were given essential treatments,and the treatment group was given＂Wenxiao Decoction＂additionally,with a course of six months. The contents of FIB,D-Dimer and blood viscosity were detected before and after treatment. Results： After treatment,the contents of FIB and D-Dimer were lower in the treatment group compared with the control group（ P 〈 0. 05）. After treatment,the contents of total blood viscosity of medium shear,plasma viscosity and whole blood reductive viscosity of low shear decreased in the treatment group compared with before treatment（ P 〈 0. 05 or 0. 01）,and the blood viscosity indexes in the treatment group were all lower than the control group（ P 〈 0. 01）. Conclusion： ＂Wenxiao Decoction ＂ could be used to treat CAS plaque which decreased FIB,D-Dimer and blood viscosity.
出处
《上海中医药大学学报》
CAS
2016年第4期18-21,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市卫计委中医药科研基金资助项目(2012QL022A)
