摘要
目的探讨缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)表达及其与肺癌生物学行为的相关性。方法采用免疫组织化学方法对68例肺癌组织和50例正常肺组织的HIF-1α及VEGF进行检测。结果肺癌组织中HIF-1α阳性率为69.1%,显著高于正常肺组织(P<0.01);肺癌组织与正常肺组织中VEGF阳性率分别为70.6%和4.0%,差异有统计学意义(P<0.01);HIF-1α和VEGF表达与肺癌组织的临床分期、组织分化及淋巴转移密切相关(P<0.05);肺癌组织HIF-1α和VEGF的表达显著相关(P<0.05)。结论 HIF-1α和VEGF参与了肺癌的发生发展,与肿瘤组织分化、侵袭转移等生物学行为密切相关,可作为反映肺癌预后的重要指标。
Objective To explore the expression and correlation of hypoxia inducible factor-let （HIF-la） and vascular endothelial growth factor（VEGF） with biological behavior of lung lancer. Methods Immunohistochemical method were used to detect the HIF-1αand VEGF in 68 cases of lung cancer tissues and 50 cases of normal lung tissues. Results Positive rate of HIF-lodn lung cancer tissues was much higher than normal lung tissues（69. 1%, P 〈0. 01 ） ; Positive rate of VEGF were 70. 6% and 4. 0% in lung cancer tissues and normal lung tissues respectively with significant difference（ P 〈 0.01 ） ; The expression of HIF-1 α and VEGF were positively correlated with clinical stage, tissue differentiation and lymphatic metasta- sis（P 〈 0. 05 ）. Conclusions HIF-1 α and VEGF participate in the occurrence and development of lung cancer, and have a close relationship with biological behavior. HIF-1α and VEGF can be important indexes for judging the prognosis.
出处
《中国肿瘤临床与康复》
2013年第2期113-115,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肺肿瘤
缺氧诱导因子-1Α
血管内皮生长因子
Lung neoplasms
Hypoxia inducible factor-let
Vascular endothelial growth factor
