摘要
目的探讨眼眶孤立性神经纤维瘤的影像学表现及病理特征。方法对40例眼眶孤立性神经纤维瘤患者的临床表现、磁共振成像(MRI)、病理切片结果行统计分析。结果 40例患者主要症状表现为单眼渐进性突出,可触及到索状物及小结节,无痛表现。其中24例视力障碍,30例眼球向正前方突出,10例眼球向外下方突出,且呈渐进性加重。眼球突出度12～20mm,平均(18.1±0.4)mm。MRI检查示:20例患者由于视神经受压而向健侧移位、弯曲,10例眼球后上部边界尚清,内部信号不均匀,10例因视神经受压而向内下方移位。病理组织学观察显示,总体上,患者瘤细胞活跃,生长丰富,可见核分裂。其中30例镜下可见大量染色深的梭形细胞,两端尖,波浪状,可视细胞束状排列,间质可见胶原纤维聚集及少量黏液基质,10例患者细胞栅栏状排列,亦可见间质聚集较多的胶原纤维。结论眼眶孤立性神经纤维瘤其临床症状表现、影像学特点与一般眶内良性肿瘤区别不大,易混淆,确诊必须依靠病理检查。肿瘤的病理构成与MRI信号有一定的关系。
Objective To explore the imaging manifestations and pathological features of orbital isolated neurofibro- matosis. Methods Clinical manifestations, magnetic resonance imaging （MRI）, and pathological section of 40 cases of pa- tients with orbital isolated neurofibromatosis were counted. Results The main symptoms of 40 cases of patients were monocular progressive outstanding, the line material and small nodules could be touched, with painless performance, in which, there were 24 cases of visual disturbance, 30 cases of eyeball ahead outstanding, 10 cases of eyeball below outstanding with progressive increasing. Eye standout was 12-20 mm, with average of （18.1±0.4） mm. MRI showed that： 20 cases of patients were side shifted bending due to the optic nerve compression, 10 cases were eyeball upper boundary with clear, and the internal signal was not uniform, 10 cases were interiorly shifted of optic nerve compres- sion. The pathological and histological observation showed that, in general, tumor ceils of patients were active, growth were rich, nuclear fission were visible, of which, there were a lot dyeing deep spindle cells under microscopical, with pointed at both ends and wavy, cells with beam pattern were visual, collagen fiber and small amount of slime matrix were gathered in interstitial, cells of 10 patients were fence pattern, more collagen fiber gathered in interstitial were also visible. Conclusion The clinical symptoms, imaging characteristics of orbital isolated nerve fibroma are not dif- ferent with general orbital benign tumor, and are easy for confusion, its diagnose must rely on pathological examina- tion. Tumor pathology constitution and MRI signal has a certain relationship.
出处
《中国当代医药》
2013年第5期54-55,共2页
China Modern Medicine
关键词
眼眶
孤立性神经纤维瘤
磁共振成像
病理
Orbit
Isolated nerve fibroma
Mri （magnetic resonance imaging）
Pathology
