摘要
目的:探讨丛状神经纤维瘤的临床病理学特征。方法:对12例丛状神经纤维瘤的临床表现、病理学特征进行观察和分析,并结合文献进行讨论。结果:丛状神经纤维瘤一般在儿童期发病,好发头颈部、四肢和躯干。组织学表现为由Schwann细胞、纤维母细胞及胶原纤维构成的丛状结构。免疫组化标记显示:梭形细胞以S-100蛋白阳性为主,vimentin、EMA、NSE或NF散在阳性。结论:丛状神经纤维瘤有特殊的临床病理学特征,提高对丛状神经纤维瘤的认识有助于排查神经纤维瘤病1型。
Objective： To explore the clinicopathological features of plexiform neurofiroma （PNF）. Methods： The clinical manifestatous and pathological charactors of 12 cases of PNF were observed and analysed combined with review of the literature. Results：PNF developed in childhood generally and often occurred at head and neck,limbs and trunks. The tumor appeared plexiform pattern consisted of Schwann cells,fibroblasts and collagen fibers. The spindle cells expressed S-100 protein diffusely and vimentin, EMA, NSE and NF scattered. Conclusions：PNF is a tumor with special clinicopathological characteristics ,which is helpful to recognize the neurofibromatosis 1 （ NF1 ）.
出处
《蚌埠医学院学报》
CAS
2007年第2期156-158,F0004,共4页
Journal of Bengbu Medical College
