摘要
目的观察右美托咪定滴鼻对舒芬太尼引起咳嗽反射的影响。方法择期手术患者100例,随机均分为两组,分别在麻醉诱导前右美托咪定1μg/kg滴鼻(D组)或等量生理盐水滴鼻(C组),15～30min后两组均在3s内静脉推注舒芬太尼0.3μg/kg,观察1min内咳嗽反射的发生情况。结果 D组咳嗽反射发生率明显低于C组(12%vs.28%,P<0.05)。两组咳嗽程度和发生时间差异无统计学意义。结论右美托咪定滴鼻可抑制舒芬太尼诱发的咳嗽反射。
Objective To evaluate the effect of intranasal dexmedetomidine on preventing sulfentanil-induced cough. Methods One hundred patients underwent elective surgery were randomly divided into 2 groups. Patients in group D received intranasal dexmedetomidine 1 μg/kg while the same volume NS were given nasally（group C） 15-30 rain prior to induction of anesthesia. Then, sulfentanil （0.3μg/kg） was infused within 3 seconds. The occurrence, time and severity of cough were recorded after sulfentanil bolus. Results The incidence of cough in group D was significantly lower than that in group C（P〈0. 05）. There was no statistical significance in the degree of cough and the occurrence time between the two groups. Conclusion Intranasal dexmedetomidine can prevent sulfentanil-induced cough.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2012年第12期1170-1171,共2页
Journal of Clinical Anesthesiology
