摘要
目的:探讨白血病抑制因子(LIF)及其受体(LIFR)与慢性输卵管炎和输卵管异位妊娠的关系。方法:采用免疫组化技术检测15例正常非孕妇女、20例慢性输卵管炎患者和40例输卵管异位妊娠患者的输卵管组织中LIF和LIFR的表达水平,半定量分析其在各组间的表达差异。结果:LIF和LIFR在各组输卵管腺上皮和间质细胞均有表达,且主要定位于腺上皮细胞胞浆。无论是月经分泌期还是增生期,慢性输卵管炎组输卵管腺上皮和间质细胞中LIF的表达明显强于正常组和输卵管妊娠组(P<0.05)。慢性输卵管炎组输卵管腺上皮中LIFR的表达显著高于输卵管妊娠组和正常非孕组(P<0.05);而在输卵管间质中,LIFR在正常非孕组的表达明显高于输卵管妊娠组和慢性输卵管炎组(P<0.01)。结论:慢性输卵管炎的输卵管微环境改变可能是输卵管炎患者易发异位妊娠的原因。
Objective：To explore the roles of LIF and LIFt（ in the development o! chronic salpingltis and ectopic pregnancies. Methods： Immunohistochemical analysis was em- ployed to probe the differential expression of LIF and LIFR in oviduct tissues from women with no pregnancy （ n=15） , chronic salpingitis （ n = 20） and ectopic pregnancy （ n = 40 ） , respec- tively. Results：The expressions of LIF and LIFR were observed in both the epithelium and in- terstitial cells of oviduct tissues, mainly localized in the cytoplasm of the glandular epithelium cells. Significant elevated expression of LIF in the epithelium and interstitial cells were observed in the chronic inflammation group compared with that in the normal group and ectopic pregnan- cy group（ P〈0.05 ）. The expression of LIFR in the glandular epithelium in the chronic inflam- mation group was significantly higher than that in the normal group and the ectopic pregnancy group（P〈0.05 ）. However, in the interstitial cells, significant increased LIFR expression was found in normal group compared with that in the chronic inflammation group and ectopic preg- nancy group （P〈0.01）. Conclusion：The disturbance of the local microenvironment of the fallo- pian tube with chronic salpingitis might be responsible for the fact that patients with salpingitis are more susceptible to tubal pregnancy.
出处
《现代妇产科进展》
CSCD
2012年第12期933-935,940,共4页
Progress in Obstetrics and Gynecology
基金
江苏省常州市科技局科研基金(No:CS20092013)
