摘要
免疫细胞和许多肿瘤细胞固有表达TLR9信号通路，TLR9介导激活固有免疫并增强获得性免疫反应，TLR9也参与调控肿瘤细胞恶性生物学行为，TLR9配体内化、受体蛋白裂解与突变、昼夜节律钟等调节TLR9信号级联。
Toll-like receptor （TLR）-9 is expressed mainly on B cells, macrophages and dendritic cells and activates these ceils upon ligand binding. The activation of TLR9 basically initiates innate immune response, but can also induce adaptive immune response. TLR9 has also been found on tumor cells, but its role on tumor cells is still unclear. In some tumor types TLR9 promotes tumor proliferation and survival. TLR9 receptor signaling on CpG ODN activation is regulated by internalization of CpG ODNs, proteolytic cleavage of the TLR9 ectodomain, and the circadian clock.
出处
《国际呼吸杂志》
2012年第22期1747-1750,共4页
International Journal of Respiration
基金
国家自然科学基金面上项目（81071744）
上海市浦东新区卫生系统学科带头人计划（PWRd2010-01）
上海市青年科技启明星计划（跟踪）（10QH1402000）
上海市科委基础研究重点项目（11JC1410900）
关键词
TLR9
信号转导
调控
TLR9
Signaling pathway
Regulation
