摘要
目的分析Toll样受体(TLRs)mRNA在宫颈鳞癌和宫颈炎组织中的表达差异及与HPV16感染之间的关系,为研究TLRs在宫颈鳞癌发生发展中的作用提供依据。方法以RT-PCR方法检测80例临床组织样本中HPV16 E6和E7的表达及TLRs mRNA的表达,分析各组表达率的差异。结果未发现鳞癌组和宫颈炎组HPV16感染与TLRs mRNA表达具有相关性;鳞癌中TLR3 mRNA表达率低于宫颈炎组(P<0.05);TLRs mRNA在中分化与低分化鳞癌中的表达差异有统计学意义(P<0.05)。结论 TLR3mRNA可能与宫颈鳞癌的发病机制有关,TLRs mRNA和HPV16在宫颈鳞癌中的表达未见相关性。
Objective To analyze the relationship between Toll like receptors（TLRs）mRNA expression levels and HPV16 infection in cervical squamous cell cancer（SCC）.Methods Expression levels of TLRs mRNA and HPV16 in tissue samples collected from cervical squamous carcinoma and cervicitis were detected,and the relationship of TLRs mRNA expression and HPV infection was analyzed in two different disease groups.ResultsExpressions of TLRs mRNA were not related to HPV16 infection in cervical squamous cell cancer.Expression of TLR3 mRNA in cervical SCC was significantly lower than those of cervicitis.Expression of TLR5 mRNA was shown significant difference between moderately differentiated and poorly differentiated cervical SCC（P〈0.05）.Conclusion Expressions of TLRs mRNA were not related to HPV16 infection in cervical SCC.TLR3 may play a role in the pathogenesis in cervical SCC.
作者
王涛
郄明蓉
WANG Tao;QIE Ming-rong(Laboratory of Molecular Translational Medicine,Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,China;Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2018年第4期649-651,672,共4页
Journal of Sichuan University(Medical Sciences)
