摘要
应激可以引起实验动物出现氧化应激。应激后机体多个环节能量代谢的改变是其引起氧化应激的机制之一。糖皮质激素参与了应激后氧化应激的发生。检测机体活性氧（ROS）水平，抗氧化能力及氧化应激损害标志物含量，可用来评估氧化应激发生及其危害。本文将就近年来实验动物应激如何引起氧化应激、其发生机制及监测方法等领域的研究进展作一综述。
Stress could induce oxidative stress in laboratory animals. Changes in energy metabolism in several aspects of the organism are one of the mechanisms through which the stress induces oxidative stress. Glucocorticoids take part in occurrence of oxidative stress after stress. Reactive oxygen species （ROS） levels, antioxidant capacity and contents of biomarkers of oxidative stress injury can be used to evaluate occurrence and damage of the oxidative stress. It was reviewed in this article that progress in the fields of how strees induce oxidative stress in laboratory animals, the mechanisms and the monitoring methods in recent years.
出处
《实验动物与比较医学》
CAS
2012年第6期549-552,共4页
Laboratory Animal and Comparative Medicine
基金
国家科技部项目（2012ZX09302002）,上海市科委实验动物项目（10140901000）
关键词
应激
氧化应激
实验动物
Stress
Oxidative stress
Laboratory animals
