摘要
目的:探讨丹参治疗冠心病的有效成分并对其药理学进行分析。方法:①密闭微波辅助萃取丹参有效成分丹参酮;②培养小白鼠心肌细胞,制造小白鼠心肌细胞缺氧再灌注损伤模型,来模拟体内冠心病所致的心肌缺血再灌注损伤;③用丹参喂养小白鼠,观察其毒副反应;④观察丹参对小白鼠精子的致畸作用。结果:丹参治疗冠心病的有效成分丹参酮能有效的抑制心肌的损伤,损伤抑制率84.3%;经毒理学研究证明药用丹参安全无毒;对小白鼠精子无致畸作用。结论:丹参治疗冠心病药效肯定且无毒。
Objective：To investigate the active ingredients and the pharmacology of Danshen on treating coronary heart disease.Method：①The closed microwave assisted extraction Salvia the active ingredient tanshinone;②Cultured mouse cardiomyocytes,manufacturing mice myocardial hypoxia-reperfusion injury model,to simulate myocardial ischemia-reperfusion injury that caused by vivo coronary heart disease;③Used salvia feeding mice,to observe toxicity;④To observe teratogenic effects of salvia against mice sperm.Results：The effective tanshinone of salvia that treated coronary heart disease can inhibit of myocardial damage,the inhibitory rate was 84.3%,toxicological studies to prove that medicinal salvia was safe and non-toxic,non-teratogenic,effected on mouse sperm.Conclusion：The pharmacod-ynamic of Danshen sure and nontoxic.
出处
《中医临床研究》
2012年第21期32-33,共2页
Clinical Journal Of Chinese Medicine
关键词
冠心病
丹参
有效成分
药理
毒理
Coronary heart disease
Salvia
Effective component
Pharmacology
Toxicology
