摘要
目的:探讨了肺癌患者手术治疗前后血清TGF-α、TGF-β1和SE-Cad水平的变化及意义。方法:应用放射免疫分析和酶联法对32例肺癌患者进行了手术治疗前后血清TGF-α、TGF-β1和SE-Cad检测,并与35名正常健康人作比较。结果:肺癌患者在手术前血清TGF-α、TGF-β1和SE-Cad水平非常显著地高于正常人组(P<0.01),经手术治疗6个月后则与正常人组比较无显著性差异(P>0.05)。结论:检测肺癌患者手术治疗前后血清TGF-α、TGF-β1和SE-Cad水平的变化对观察病情和预后判定具有重要的临床价值。
Objective To explore the significance of post-operative changes of serum TGF-α,TGF-β1 and SE-Cad levels in patients with lung cancer.Methods serum TGF-α,TGF-β1（with RIA） and serum SE-Cad（with ELISA） levels were determined both before and after operation in 32 patients with lung cancer and 35 normal healthy controls.Results Before operation the serum TGF-α,TGF-β1和SE-Cad levels in the patients were significantly higher than those in controls（P〈0.01） 6 months after operation the difference between the levels in patients and controls were not significant（P〉0.05）.Conclusion changes of serum TGF-α,TGF-β1 and SE-Cad contents after operation might be importance of monitoring pathosis and prognosis in patients with lung cancer clinically.
出处
《放射免疫学杂志》
CAS
2012年第4期398-399,共2页
Journal of Radioimmanology
关键词
肺癌转化生长因子-α
转化生长因子-Β1
可溶性上皮黏蛋白
lung cancer
transforming growth factor-α（TGF-α）
transforming growth factor-β1（TGF-β1）
soluble epicyte cad-herin（SE-Cad）
