摘要
目的观察危重期肺癌患者抢救性化疗的效果。方法选取2012年6月—2014年6月广西壮族自治区肿瘤医院、广西民族医院、广西中医药大学第一附属医院收治的80例危重期肺癌患者为研究对象,采用随机数字表法分为观察组和对照组,每组40例,对照组患者采用多西他赛+顺铂常规化疗方案,观察组采用多西他赛+奥沙利铂抢救性化疗方案,观察两组患者的化疗效果、疾病无进展生存期(TTP)、总生存期(OS)及毒副作用发生情况。结果观察组患者化疗有效率[67.5%(27/40)]高于对照组[50.0%(20/40)](χ~2=6.319,P<0.05)。观察组患者TTP、OS均长于对照组(P<0.05)。观察组患者Ⅰ~Ⅱ度粒细胞计数减少、血小板计数减少、血红蛋白降低、丙氨酸氨基转移酶(ALT)异常、尿素氮(BUN)异常、呕吐、恶心发生率低于对照组,周围神经炎、腹泻发生率高于对照组(P<0.05);观察组患者Ⅲ~Ⅳ度粒细胞计数减少、血小板计数减少、血红蛋白降低发生率低于对照组,腹泻发生率高于对照组(P<0.05)。观察组Karnofsky功能状态(KPS)评分改善率[35.0%(14/40)]高于对照组[20.0%(8/40)](χ~2=5.623,P<0.05)。结论对危重期肺癌患者应用多西他赛联合奥沙利铂抢救性化疗方案,近期疗效显著,且肝肾毒性、血液毒性等化疗毒副作用较轻,能有效提高患者的生存质量,是治疗危重期肺癌的理想化疗方案。
Objective To observe the effect of salvage chemotherapy in the treatment of patients with severe lung cancer. Methods 80 cases of severe lung cancer in Guangxi Tumor Hospital,Minzu Hospital of Guangxi Zhuang Autonomous Region,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from June 2012 to June 2014 as the research object,divided into the observation group and the control group using a random number table method,40 cases in each group. The control group were treated with docetaxel plus cisplatin chemotherapy scheme,the observation group by docetaxel plus oxaliplatin salvage chemotherapy. The chemotherapy effect,progression free time（ TTP）,overall survival（ OS）,and toxic and side effects were observed in the two groups. Results The effective rate of chemotherapy in the observation group was [67. 5%（ 27/40） ]higher than that in the control group [50. 0%（ 20/40） ]（ χ~2= 6. 319, P 〈 0. 05）. The TTP and OS in the observation group were longer than those in the control group（ P 〈 0. 05）. The incidence of Ⅰ-Ⅱ degree granulocyte count reduction,platelet count reduction, hemoglobin decreased, abnormal ALT and abnormal BUN, vomiting and nausea in the observation group were lower than those in the control group,the incidence of peripheral neuritis and diarrhea in the observation group were higher than those in the control group（ P 〈 0. 05）. The improvement rate of Karnofsky functional status（ KPS） score in the observation group was [35. 0%（ 14/40） ]higher than that in the control group [35. 0%（ 14/40） ]（ χ~2= 5. 623,P 〈0. 05）. Conclusion The critical stage of lung cancer is treated with docetaxel combined with oxaliplatin in the rescue of chemotherapy,with significant short-term efficacy and toxicity of chemotherapy toxicity of kidney and liver, blood toxicity lighter,can effectively improve the quality of life of patients,is ideal regimen in patients with severe lung cancer treatment.
出处
《中国全科医学》
CAS
北大核心
2017年第A02期42-44,共3页
Chinese General Practice
关键词
肺肿瘤
抗肿瘤联合化疗方案
多西他赛
奥沙利铂
Lung neoplasms
Antineoplastic combined chemotherapy protocols
Docetaxel
Oxaliplatin
