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慢性乙型肝炎患者血清细胞因子检测的临床意义

Clinical Significance of Determination of Serum TGF-α and IL-8 Levels in Patients with Chronic Hepatitis B
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摘要 目的:探讨慢性乙型肝炎患者血清转化因子(αTGF-)α和白细胞介素-8(IL-8)水平的变化。方法:应用放免法对44例慢性乙型肝炎患者进行了血清TGF-α和IL-8水平检测,并与34名正常人作比较。结果:慢性乙型肝炎组患者血清TGF-α和IL-8水平均显著地高于正常人组(P<0.01)。结论:检测慢性乙型肝炎患者血清TGF-α和IL-8水平对疾病的预后估计具有重要临床意义。 Objective: To explore the clinical significance of the changes of serum TGF-α and IL-8 levels in patients with chronic hepatitis B. Methods: Serum TGF-α and IL-8 levels were detected with RIA in 44 patients with chronic hepatitis B and contrasted with 34 controls.Results: The levels of serum TGF-α and IL-8 were significantly higher in the patients than those in controls (P〈 0.01 ).Conclusion: Detection of serum TGF-α and IL-8 levels has important clinical relevance to the prognosis of chronic hepatitis B.
出处 《大理学院学报(综合版)》 CAS 2008年第4期9-10,14,共3页 Journal of Dali University
关键词 慢性乙型肝炎 细胞因子 转化生长因子-Α 白细胞介素-8 chronic hepatitis B cytokine transforming growth factor alpha interleukin-8
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  • 1梁启廉,陈小东,李杰,何悦慨,李建文,揭育丽,康旭.食管癌患者血清TGF-α水平检测的临床价值[J].实用癌症杂志,2005,20(2):158-160. 被引量:1
  • 2De-Paulsen N, Brycehzy A, Foumier MC, et al. Role of trandorming growth factor-alpha in von Hippel-Lindau(VHL) (-/-) clear cell renal carcinma cell proliferation: a possible mechanism coupling VHL tumor supperessor inactivation and tumorigenesis [ J ].Proc Natl Acad Sci USA, 2001,98(4) :1387-1392. 被引量:1
  • 3Grasl·Kraupp B, Schausberger E, Hufnagl K, et al. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei [ J ]. Hepatology, 2002,35 :1372-1380. 被引量:1
  • 4Ghanem MA, Van-Der-Kwast TH, Den-Hollander JC, et al. Expression and prognostic value of epidermal growth factor receptor,transforming growth factor-alpha, and c-erbB-2 in nephroblastoma[J]. Cancer, 2001,92(12) :3120-3129. 被引量:1
  • 5Hofer DR, Sherwood ER, Bromberg WD, et al. Autonomous growth of androgen-independent human prostatic carcinoma cell:role of transforming growth factor-alpha[J]. Cancer Res, 1991,51:2780-2785. 被引量:1
  • 6Jhappan C, Stabbe C, Harkins RN, et al. TCF-α overexpression in transgenic mice induces livemeoplasm and abnormal development of the mammary gland and pancreas[J]. Cell, 1990, 61,1137. 被引量:1
  • 7Chuang LY, Tsai JH, Yeh YC, et al. Epidermal growth factor related transforming growth in the urine of patients with hepatocellular carcinoma[ J ]. Hepatology, 1991,13 (3) : 1112. 被引量:1
  • 8Arends JW. Molecular interactions in the Vogelstein model of colorectal carcinoma. J Pathol,2000, 190(4):412-416. 被引量:1
  • 9Kim KY ,Jeong SY, Won J,et al. Induction of angiogenesis by expression of soluble type II transforming growth factor-beta receptor in mouse hepatoma.J Biol Chem, 2001,276(42):38781-38786. 被引量:1
  • 10Akiba J,Yano H,Ogasawara S, et al. Expression and function of interleulin-8 in human hepatocellular carcinoma. Int J Oncol, 2001,18(2):257-264. 被引量:1

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