摘要
本实验在于阐明频域心电图(FCG)可以反映冠状动脉血流量(CBF)。狗的冠状动脉(CA)左前降支予以轻度狭窄,R_x、R_(xy)、F_(min)值都增大,说明FCG这些参数的变化比由CA左旋支狭窄引起的变化提前出现(左旋支在中度狭窄时才出现FCG的变化)。当狭窄程度达到中度或重度时,除了R_y在中度狭窄不发生明显变化外,其余指标都显著增大(p<0.05),F_(min)和R_(xy)增大程度尤其明显(p<0.01),心率(HR)和CBF显著下降,主动脉平均压(P_a)轻度下降。 在CBF减少的情况下,通过CA灌注硝酸甘油(8μg/min)10min后,HR、CBF、R_x、R_y、R_(xy),和F_(min)没有明显变化,而小冠状动脉远端平均压(P_c)降低(p<0.01),p_x、P_y也降低(p<0.05)。在相同情况下,灌注烟浪丁,HR和P_a几乎不变,P_c和CBF明显上升;除F_(min)外,FCG所有的指标都增大(p<0.05)。在CA狭窄的情况下,麦角新碱可诱发血管收缩,反映在P_a、HR和CBF轻度下降和P_c、P_x、P_y、R_x、F_(min)、R_y和R_(xy)显著上升,CA灌注麦角新碱(0.2μg/min)后,FCG的指标随着缺血程度的改变而变化。
Experiments were designed to indicate that frequency-domain correlative cardiogram (FCG) can reflect coronary blood supply. In 8 dogs with left anterior descending (LAD) coronary artery narrowed to a mild degree, Rx, Rxy and Fmin increased and these changes of FCG indexes appeared earlier than those caused by left circumflex coronary artery (LCX) stenosis. When stenosis was moderate or severe, all FCG indexes except Ry increased signi-ficantly(p<0.05), especially Fmin and Rxy (p<0.01). With the occurrence of stenosis, the heart rate (HR) and coronary blood flow (CBF) decreased greatly and the mean aortic pressure (Pa) dropped slightly.The effects of intracoronary infusion of nitroglycerin during partial reduction of arterial flow in anesthetized dogs were studied. When nitroglycerin (8 μg/min) was infused for 10 min, HR, CBF, Rx, Ry, Rxy and Fmin had no significant changes, while Px, Py (p <0.05) and mean distal arterial pressure (Pc, p<0.01) reduced remarkably. When nicoran-dil was used in another experiment under the same condition, HR and Pa almost unchanged, Pc dropped and CBF increased remarkably. All FCG indexes except Fmin augmented significantly (p<0.05). Myocardial ischemia produced by ergonovine-induced vasoconstriction during pre-existing coronary stenosis was reflected by the experimental results that Pa,HR and CBF dropped slightly but Pc, Pi, Py, Fmin, Rx, Ry and Rxy increased significantly (p< 0.05). Intracoronary infusion of ergonovine (0.2μg/min) resulted in changes of FCG indexes with degree of myocardial ischemia.
出处
《中国应用生理学杂志》
CAS
CSCD
1990年第3期240-244,共5页
Chinese Journal of Applied Physiology
关键词
频域心电图
冠状动脉狭窄
药物
stenosis
nicorandil
ergonovine
nitroglycerin
frequency-domain correlative cardiogram
