摘要
13只开胸犬,钝性分离冠状动脉(前降支或左旋支),用微米缩窄器造成急性心肌缺血。采用多普勒标准化峰值充盈率(PFR)评价左室舒张充盈功能。结果显示由舒张早期峰值血流速度(EPV)除以二尖瓣(MV)血流、速度时间积分的标准化而导出新多普勒PFR,克服了包括MV环径测量和几何形状的假设引起的误差。该指标不受取样容积(SV)的位置影响,SV从MV环移到MV尖部时,EPV增加25%。E/A比值增加44%。多普勒PFR与二维超声心动图前半充盈分数相关较好(r=0.84),与多普勒1/3充盈分数呈线性关系(r=0.81)。
In thirteen openchest dogs, the coronary artery (LCX or LAD) was dissected and external stenosis was produced by a micrometer constrictor around the coronary artery to cause acute myocardial ischemia, The left ventricular diastolic function was assessed by Doppler normalizing peak filling rate (PFR). It was show that the new Doppler PFR is achieved, by simply dividing early peak filling velocity (EPV)by the time velocity integral of mitral inflow. This normalization process overcomes a major technical obstacle by elimination error involved in diameter measurement and geometric assumption. This variable was not influenced by the sample volume (SV) position. whereas a 25% increase is seen in EPV and a 44% increase occurs in E/A ratio as the SV is moved from the anulus to the leaflet tips. There was an excellent correlation between Doppler PFR and half filling rate derived from two — dimensional echocardiography (r=0.84) and there was aclose linear correlation between normalizing PFR and one third filling fraction derived from Doppler (r=0.81). Because mitral inflow velocity are highly reliable and reproducible, this ability overcomes a previous major technical limitation and allows a more reliable Doppler assessment of PFR.
出处
《中国临床医学影像杂志》
CAS
1992年第2期90-93,112,共5页
Journal of China Clinic Medical Imaging
