摘要
目的调查北京部分社区60岁以上老人促红细胞生成素(EPO)水平,并分析老年贫血的相关因素。方法 2011年2月至2011年9月,通过随机抽样方法对从北京市朝阳区411名社区老人进行问卷调查、实验室检查,包括人口学资料,血红蛋白(Hb)、铁蛋白(FER)、叶酸(FOL)、维生素B12(VB12)、肌酐(Cr)和白细胞(WBC)等内容;采用酶联免疫吸附实验定量(ELISA)测定血清EPO水平及采用Logistic回归分析老年贫血的相关因素。结果北京社区60岁以上老年人群EPO95%医学参考值范围,男性:2.37～29.83mIU/ml,女性:2.40～26.96mIU/mL。贫血患病率为8.52%,男性、女性患病率分别为:7.99%、8.97%,无统计学差异(P>0.05)。贫血组与非贫血组人群EPO、WBC水平的差异有统计学意义(P<0.05)。Logistic回归分析显示,老年贫血发生的相关因素有EPO、年龄、VB12(P<0.05)。结论北京社区老年贫血患者EPO水平显著高于非贫血人群,老年贫血与年龄、血EPO及VB12水平相关。
Objective To survey the level of erythropoietin（EPO） in aged people（over 60 years old） in part communities of Beijing and analyze the relevant factors of anemia.Methods The aged people（n=411） from Chaoyang District of Beijing were given questionnaire and laboratory examination by using randomized sampling method from Feb.2011 to Sept.2011,and the data included demographic materials,hemoglobin（Hb）,ferritin（FER）,folic acid（FOL）,Vitamin B12（VB12）,creatinine（Cr） and white blood cells（WBC）.The level of EPO was detected by using enzyme-linked immunosorbent assay（ELISA） and relevant factors of anemia were analyzed by using Logistic regression.Results The 95%medical reference range of EPO in aged people in Beijing communities was as follows：2.37 mIU/mL～29.83 mIU/mL in the male and 2.40 mIU/mL～26.96 mIU/mL in the female.The morbidity of anemia was 8.52%,and 7.99% in the male and 8.97% in the female（P〉0.05）.The difference in levels of EPO and WBC had statistical significance between anemia group and non-anemia group（P〈0.05）.The analysis of Logistic regression showed that the relevant factors of senile anemia included EPO,age and VB12（P〈0.05）.Conclusion The level of EPO is significantly higher in aged people with anemia than that in people without anemia.The senile anemia is correlated to age and levels of EPO and VB12.
出处
《中国循证心血管医学杂志》
2012年第2期158-160,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
首都医学发展科研基金(2009-1009)
