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贫血对高龄女性认知功能的影响 被引量:6

Association of anemia with cognition among senior female in China
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摘要 目的分析我国长寿地区90岁以上老年女性贫血对其认知功能的影响。方法利用2008—2009年中国老年人口健康影响因素跟踪调查(CLHLS)项目研究数据,包括5个长寿地区的90岁以上老年女性383名。使用简易精神状况检查法(MMSE)量表收集研究对象认知功能信息,进行医学体格检查,测定血红蛋白等血生化指标。分析贫血组和非贫血组老人认知功能的差异,采用非条件logistic回归分析贫血对老年女性认知功能的影响。结果在383名研究对象中,贫血组141例,非贫血组242名;贫血组认知功能评分为(9.65±9.32)分,非贫血组为(13.06±10.25)分(X^2=5.59,P〈0.05);贫血组认知功能较差的比率为84.4%(119/141),非贫血组为72.3%(175/242)(X^2=8.08,P〈0.05)。多因素分析显示,在调整年龄、文化程度、婚姻状况、吸烟和饮酒后,贫血组发生认知功能受损的风险约是非贫血组的2倍(OR=2.016,95%口:1.185-3.431,P=0.010)。结论贫血会增加我国长寿地区高龄女性认知功能受损的发生风险。 Objective To explore the relationship between anemia and cognitive function among senior female aged 90 years old and above in longevity regions in China. Methods 383 senior female in 5 longevity areas from the Chinese Longitudinal Healthy Longevity Survey ( CLHLS ) 2008 - 2009 were included in the study. The cognitive function was assessed by mini mental state examination (MMSE) scale. All subjects were administered the physical examinations and biochemical testing of blood, including the hemoglobin. The difference of cognitive function between those with and without anemia was analyzed. Logistic regression was used to analyze the relationship between anemia and cognitive function. Results The 383 subjects were divided into two groups, 141 in anemia group and 242 in group without anemia. The total score of cognitive function was 9. 65 ±9. 32 in anemia group,and 13.06± 10. 25 in group without anemia (X^2 = 5.59, P 〈 0. 05 ) . The percentage of cognition impairment was 84. 4% (119/141 ) in anemia group, and 72. 3 % ( 175/242 ) in group without anemia ( X^2 = 8.08, P 〈 0. 05 ). In the multivariable logistic regressions, after adjustment for age, education, marital status, smoking and alcohol drinking, the risk for cognition impairment in anemia group was about twice of that in group without anemia ( OR = 2. 016,95% CI: 1.185 - 3.431, P = 0. 010 ). Conclusion Anemia increases the risk of cognition imoairment among senior female in Chinese longevity areas.
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2011年第9期802-805,共4页 Chinese Journal of Preventive Medicine
基金 国家自然科学基金(70533010)
关键词 贫血 认知 长寿 老年人 女(雌)性 Anemia Cognition Longevity Aged Female
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