摘要
有实验表明贫血经常在慢性心力衰竭患者出现。在这些患者的贫血用促红细胞生成素(EPO)治疗时,能观察到其心功能和症状明显改善。过去我们认为EPO特异性作用于造血细胞,最近的研究表明其具有几种非造血方面的作用,包括抗凋亡作用、促血管生成作用,这可能对缺血性心脏病患者有潜在的应用价值。这些发现表明EPO在校正血红蛋白水平作用之外可能对心血管病有潜在的积极作用。
Several studies showed that anemia is commonly observed in patients with chronic heart failure. When anemia in these patients is treated with erythropoietin（EPO） ,a significant improvement in cardiac function and symptoms was observed. Although it was originally believed that EPO specifically acted on haematopoietical cells,recent evidence demonstrated several non-haematopoietical effects including anti-apoptotic effects and pro-angiogenic effects which could be of potential value in patients with ischemic heart disease. These findings suggest that EPO may have potential effects in cardiovascular disease beyond correction of haemoglobin levels.
出处
《心血管病学进展》
CAS
2006年第1期37-40,共4页
Advances in Cardiovascular Diseases
