摘要
目的 探讨自然人群血尿酸对冠状动脉钙化的影响.方法 2012年4-7月对903名（男37 ～ 76岁,女42～76岁）北京市西山社区人群进行心血管危险因素调查、血生化检查及CT冠状动脉钙化扫描.结果 尿酸水平位于第1四分位数（1 Q）、2～3Q、4Q人群的冠状动脉钙化率分别为37.2％、45.5％、60.6％（P＜0.001）,冠状动脉钙化积分分别为（109.7±333.1）AU、（133.9±356.9）AU、（200.8±459.4）AU（P＜0.001）.单因素logistic回归分析显示随尿酸水平升高冠状动脉钙化风险增加（2～3 Q：OR=1.41,95％CI：1.02～1.95,P=0.040；4 Q：OR=2.60,95％CI：1.78～3.80,P＜0.001）,但多因素logistic回归分析中尿酸与冠状动脉钙化的关系消失（2～3 Q：OR=0.92,95％CI：0.60～ 1.43,P=0.713;4 Q：OR=1.38,95％CI：0.80～ 2.39,P=0.247）.结论 北京市社区人群冠状动脉钙化率及钙化程度随尿酸水平升高而增加,但血尿酸水平并非冠状动脉钙化的独立危险因素.
Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population （aged 37-76 years for men,aged 42-76 years for women） in Xishan community,Beijing,were selected to accept a survey on the risk factors of cardiovascular.Blood tests and CT coronary artery calcium scans were carried out.Results At the 1 Quartile （1 Q）,2 to 3 Quartile （2-3 Q） and 4 Quartile （4 Q） of uric acid levels,the prevalence rates of coronary artery calcium were 37.2%,45.5%,60.6% （P〈0.001） and the coronary artery calcium scores were （1 09.7 ± 333.1）AU,（133.9 ± 356.9） AU,（200.8 ± 459.4） AU（P〈0.001） respectively.Data from the univariate logistic regression analysis showed that with the increase of uric acid,the prevalence rates of coronary artery calcium also increased （OR2-3Q=1.41,95% CI：1.02-1.95,P=0.040; OR4Q=2.60,95% CI：1.78-3.80,P〈0.001）.However,the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis （OR2-3Q=0.92,95%CI：0.60-1.43,P=0.713; OR4Q=l.38,95% CI：0.80-2.39,P=0.247）.Conclusion Uric acid did not seem to be an independent risk factor for coronary artery calcium,although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2013年第6期566-568,共3页
Chinese Journal of Epidemiology
基金
国家“十一五”科技支撑计划（2007BAl05802）
关键词
尿酸
冠状动脉钙化
自然人群
Uric acid
Coronary artery calcification
Natural population
