摘要
目的:观察精氨酸强化的肠外营养对大肠肿瘤病人手术并门静脉化疗后免疫功能的影响。 方法:随机选择大肠癌病人36 例,分为常规(PN)组(n= 19)和精氨酸强化的PN 组(n= 17),加入精氨酸20 g/60 kg 体重于3 L袋中,PN 支持1 周。在术前、术后1、4、7 天测定IgG、IgA、IgM、IgE,CH50、C3、C4,T淋巴细胞及其亚群(CD3+ 、CD4+ 、CD8+ 及CD4+ /CD8+ 比值),NKC活性和IL-2。 结果:术后体液免疫和细胞免疫指标均明显下降,P<0.05。精氨酸强化的PN组在术后7天,以IgG、IgE、CH50、CD3+ 、CD4+ 及CD4+ /CD8+ 、NKC活性和IL-2回升显著,接近于术前值,明显高于常规PN组(P< 0.05)。 结论:精氨酸强化的PN,改善了大肠癌根治术同时行门静脉化疗病人的免疫功能。
Objectives:To study the effects of L arginine onthe immunofunction in patients with colorectal cancer after operation and portal vein chemotherapy. Methods:Thirty six patients received either a standard PN or PN supplemented with 20 g/60 kg body weight of L arginine for 7 days after colorectal cancer operation and portal vein chemotherapy.Immunofunction(IgG,IgA,IgM,IgE;CH50,C3,C4;CD3 +,CD4 +,CD8 +);NKC,IL 2 were tested. Results:The patients immunofunction was decreased after operation and chemotherapy( P <0.05).The group supplemented with arginine had improved the immunofunction by increasing IgG,IgE,CH50,CD3 +,CD4 +,CD4 +/CD8 +,NKC and IL 2 as compared with standard PN group at the 7th day. Conclusions:Arginine has a potentially powerful therapeutic implications for the colorectal cancer after operation and portal vein chemotherapy and can enhance the effect of parenteral nutrition.
出处
《肠外与肠内营养》
CAS
2000年第1期13-16,共4页
Parenteral & Enteral Nutrition
关键词
精氨酸
免疫功能
化疗
大肠癌
L Arginine
Colorectal cancer
Immunofunction
Chemotherapy
