摘要
观察了大鼠２０％体表面积（ＢＳＡ）Ⅲ°烧伤后精氨酸（Ａｒｇ）对体内细胞因子的影响。结果表明，大鼠烧伤后，脾细胞生成白介素－２（ＩＬ－２）的能力明显下降，血清肿瘤坏死因子（ＴＮＦ）、白介素－６（ＩＬ－６）和白介素－１（ＩＬ－１）水平均显著升高，但ＩＬ－１第３天开始下降；第７天时ＩＬ－６和ＩＬ－１均低于正常对照组。当在饲料中添加２％和５％Ａｒｇ时，不仅能明显促进脾细胞合成ＩＬ－２，而且可降低血清ＴＮＦ和ＩＬ－６的含量，但对ＩＬ－１的影响不明显。实验结果提示，烧伤后补充Ａｒｇ可调节体内细胞因子的水平，但两剂量组之间没有明显差异。
In this study, we observed the effects of arginine (Arg) on cytokines after 20% BSA Ⅲ°burn in Wistar rats,Serum TNF rose significantly in burned rats, while IL-2secretion of splenocytes in vitro reduced markedly. At the same time, serum IL-1and IL-6 levels also rose obviously,But IL-1 began to fall from the 3rd day, and it was as lower than the normal control as IL-6 on the 7th day postburn, When the burned rats received diet supplen1ented with 2% or 5% Arg, not only IL-2 secretion of splenocytes improved, but also serum TNF and IL-6 levels decreased significantly, The effect of Arg on IL-1 was not obvious. These results suggested that Arg could modulate cytokine levels in burned rats, but there was no significant difference between the two dosage groups.
出处
《营养学报》
CAS
CSCD
北大核心
1996年第4期392-397,共6页
Acta Nutrimenta Sinica
基金
研究生经费资助
