摘要
目的:证实在不明原因的肝炎患者血清中一种新型病毒(TTV)的存在,分析其感染特征。方法:用地高辛素标记基因探针,斑点杂交法检测未知和已知病原的肝炎患者75例,正常对照17例。结果:92例血清TTVDNA总检出率为23.91%(22/92)。其中非甲～非戊型肝炎病人组检出率为35%(7/20),甲～戊肝组21.81%(12/55),正常对照组17.65%(3/17);急性肝炎中36.84%(7/19),慢性肝炎中21.88%(7/32),重症肝炎中40%(2/5),肝硬化中15.79%(3/19)。结论:TT病毒可能是导致病毒性肝炎的一种新型病原,可以单独感染或与其他病毒重叠感染,亦可有健康携带状态。感染后出现急性慢性甚至重度肝损伤。
Objective:To demonstrate the existence of a novel virus (transfusion transmitted virus,TTV) in patients with hepatitis,and to analyse its infectional feature. Methods:Using digoxigenin-labeled probe,75 sera of known or unknown etiology, and 17 blood donors were detected by dot blot hybridization. Results:The prevalence of TTV DNA was 23.91 % (22/92). Among them the positive rate of TTV DNA in the group without HAV^HEV was 35% (7/20),in the group with HAV ~HEV21.81% (12/55),in the blood donors 17.65% (3/17);in acute hepatitis 36.84% (7/19),in chronic hepatitis 21.88% (7/32), in severe hepatitis 40% (2/5) and in liver cirrhosis 15.79% (3/19). Conclusion:TT virus is a novel pos-sible virus which leads to hepatitis. This virus may occur single or superinfection, even be seen in blood donors. Acute and chronic infection, even severe liver injury may be present.
出处
《天津医药》
CAS
2000年第2期80-82,共3页
Tianjin Medical Journal
