摘要
目的探讨丙型肝炎病毒（ＨＣＶ）感染与肾小球肾炎病变的关系。方法应用免疫组化技术以丙型肝炎病毒抗体（抗ＨＣＶ）ＮＳ３和抗ＨＣＶＮＳ５单克隆抗体对２１例丙型肝炎患者尸检石蜡包埋肾组织中的丙型肝炎抗原（ＨＣＡｇ）进行检测。结果ＨＣＡｇ的检出率为６１９％（１３／２１），其中膜增殖性肾炎（ＭＰＧＮ）１１例，系膜增殖性肾炎（ＭｓＰＧＮ）１例，１例未见明显病变。ＨＣＡｇ阳性颗粒定位于肾小球系膜区、系膜细胞及肾小管上皮细胞胞浆内。２１例中有１７例血清乙型肝炎病毒（ＨＢＶ）标志呈阳性，同单纯ＨＢＶ感染组相比，本组患者出现肾小球肾炎病变更为多见（χ２＝８５，Ｐ＜００１）。结论ＭＰＧＮ型是ＨＣＶ感染后肾小球肾炎病变的主要类型。
Objective To investigate the existence of hepatitis C antigen (HCAg) and its relationship with glomerulonephritis in renal tissue. Methods Hepatitis C virus NS3 (HCV NS3) and hepatitis C virus NS5 (HCV NS5) were detected with immunohistochemical method in the paraffin embedded renal tissue taken from 21 autopsied cases with HCV infection. Results Among the 21 cases, 13(61.9%) had HCV NS3 or HCV NS5 in their renal tissue. HCAg were localized in the mesangial matrix and in the cytoplasm of glomerular mesangial or tubular cells. Pathological changes were found in 12 of the 13 positive cases, 11 were identified as membranoproliferative glomerulonephritis (MPGN) and 1 as mesangial proliferative glomerulonephritis (MsPGN). 17 patients were serologically superinfected with hepatitis B virus (HBV), but it seemed that the renal lesion in this group was more common than in the patients with HBV infection alone (χ 2=8.5, P <0.01). Conclusion MPGN is the major type of glomerulonephritis associated with HCV infection.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1998年第5期320-322,共3页
Chinese Journal of Internal Medicine
关键词
肾小球肾炎
免疫组化
丙型肝炎
Glomerulonephritis Hepatitis C viruses Immunohistochemistry
