摘要
中药雄黄主要成分为四硫化四砷。作为含砷矿物类中药,雄黄及其复方的毒性问题近年来倍受关注,其应用在国外也遭到了限制甚至禁止。因此,为全面正确认识雄黄及其复方的毒性,人们对其急性毒性、长期毒性、特殊毒性以及炮制、给药剂量和给药时间与毒性的关系等进行了大量的毒理学研究。此外,雄黄的毒代动力学、雄黄及其复方与化学形式的砷剂(如砷酸钠)的毒性比较等也得到了相关的毒理学研究。本文对雄黄及其复方的毒理学研究现状进行概述,对研究中存在的问题进行分析总结,并在此基础上提出了进一步研究的方向。
Realgar is one of 28 kinds toxic Chinese herbal medicines issued by the Chinese Ministry of Health,and its major component is As4S4.Due to containing arsenic,the toxicity of realgar and its compounds has recently been a hot issue of concern,and the application in foreign countries has also been limited or even banned.Therefore,in order to understand the toxicity of realgar and its compounds comprehensively and correctly,a large number of toxicology studies,about their acute toxicity,chronic toxicity,special toxicity,as well as their relationship between the toxicity and the processing method,dosage,administration time of realgar and so on,have been carried out.In addition,some other issues,such as the toxicokinetics of realgar,the comparison of toxicity for realgar and its compounds and the chemical forms of arsenic（as arsenite） and so on,have also been studied.This paper reviewed the current toxicology studies of realgar and its compounds,and the existing questions and the directions of development would also be included.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2011年第6期601-604,共4页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(30973715)
江苏省高校研究生科研创新计划资助项目
江苏高校优势学科建设工程资助项目
江苏省高校自然科学基金项目(11KJD360001)~~
关键词
雄黄
复方
药物毒性
realgar
compound prescription
drug toxicity
