摘要
目的探讨妇科门诊患者HPV感染率、亚型分布以及不同年龄HPV感染情况,为本地区妇女HPV防制提供基线资料。方法对2009年10月-2011年7月来湘潭市妇幼保健院妇科门诊就诊的9 266例患者进行登记,并采集其阴道、宫颈分泌物作为标本,用导流杂交基因芯片技术进行21种HPV基因型的分型检测。用EXCEl2007和SPSS17.0建立数据库及统计分析,HPV感染率比较采用χ2检验。结果①HPV阳性总检出率为21.07%（1 952/9 266）,高危型别感染率为18.55%（1 719/9 266）,低危型别感染率为2.51%（233/9 266）,单一型别感染率为15.55%（1 441/9 266）,多重型别感染率为5.51%（511/9 266）;②HPV感染数前三位的是HPV52、HPV16、HPV58,且以单一感染和双重感染为主,高危型和低危型感染者在HPV单一及多重感染分布上差异有统计学意义（χ2=68.37,P〈0.01）;③不同年龄检查者的HPV感染率差异有统计学意义（χ2=28.27,P〈0.01）,不同年龄的HPV感染者感染高低亚型的分布上差异有统计学意义（χ2=32.87,P〈0.01）,不同年龄的HPV感染者HPV感染类型的分布上差异有统计学意义（χ2=48.49,P〈0.01）,各年龄均以单一及高危感染为主,但在25岁以下及50岁以上年龄HPV感染者中高低危合并感染、多重感染多于其他年龄段。结论本院妇科门诊患者HPV感染率处于较高水平,HPV感染最常见的亚型为HPV52、16、58。不同年龄患者HPV感染率不同,高低危亚型、单一及多重感染分布在不同的年龄中有差别,在25岁以下及50岁以上年龄患者中高低危合并的多重感染高于25~50岁患者。
Objective To investigate HPV infection rate,subtype distribution and HPV infection status in different ages among gynecological patients,and to provide the basic data for the prevention and control of HPV infection. Methods Cervical tissue specimens from 9,266 gynecological outpatients in Xiangtan Maternal and Child Health Hospital from October 2009 to July 2011 were examined with flow-through hybridization and gene chip technique（cape medical system） to determine the 21 HPV genotypes.Excel 2007 and SPSS17.0 software were used to establish database and analyze the data.The Chi-square test was used in the comparison of the HPV infection rates among different age groups. Results Of the 9,266 specimens,HPV was detected in 1,952 specimens,with a positive rate of 21.07%（1,952/9,334）.The high-risk HPV infection rate was 18.55% （1,719/9,266）,the low-risk HPV infection was 2.51%（233/9,266）,single subtype infection rate was 15.55%（1,441/9,266）,and the infection rate of multiple subtypes was 5.51%（511/9,266）.Of all the subtypes in this study,HPV52,HPV16,and HPV58 ranked the top three HPV infection and with the single and double infection primarily,with the constituent ratio of the single and multiple infection,the patients infected high risk subtypes were statistically significant different from those infected with low-risk subtypes（χ2=68.37,P0.01）.The difference was statistically significant in the HPV infection rate among different ages（χ2=28.27,P0.01）.The constituent ratio of the HPV infections from different age groups was significantly different in the distribution of the high-risk and low-risk HPV subtypes（χ2=32.87,P0.01） and the HPV single and complex infection （χ2=48.49,P0.01）.The single and high-risk HPV infection was the main infection in different age groups.In the age group of less than 25 years and more than 50 years,the constituent ratios of the high-risk and low-risk co-infection were higher than other groups. Conclusions HPV infection rate of gynecological outpati
出处
《实用预防医学》
CAS
2011年第11期2058-2061,共4页
Practical Preventive Medicine
