摘要
目的:研究健脾化湿颗粒的制备工艺。方法:以干膏得率和芍药苷得率作为评价指标,采用L9(34)正交试验法优选健脾化湿颗粒的提取工艺;以颗粒吸湿性和成型性为指标,对干法制粒的工艺进行研究。结果:最佳提取工艺为:加10倍水,回流提取2次,每次2h;干压法制备得到的颗粒吸湿性和成型性好。结论:优选的健脾化湿颗粒工艺稳定可行,可应用于工业化生产。
Objective： To optimize the preparation process of Spleen-invigorating and Dampness-resolving Granule.Methods： The optimal extraction of Spleen-invigorating and Dampness-resolving Granule was investigated by the L9（34） orthogonal experiment.With hydroscopicity,and formability as the indexes,the dry granulating process was evaluated.Results： The optimal extraction procedures were as follows： adding 10-fold water,refluxing extraction for 2 times（2 hours per time）.The hydroscopicity and formability of the granule were in accord with manufacture requirements.Conclusion： The optimized extraction and formation processes are stable and feasible,and can be used for the industrialized production.
出处
《药学与临床研究》
2011年第5期478-480,共3页
Pharmaceutical and Clinical Research
关键词
健脾化湿颗粒
正交设计
制备工艺
Spleen-invigorating and Dampness-resolving Granule
Orthogonal design
Preparation technology
