摘要
目的研究老年人肾功能损害与冠心病患病的关系。方法选择年龄>65岁老年患者1264例,根据慢性肾脏病分期及估算肾小球滤过率(eGFR)分为5组:≥90 ml/(min·173 m^2)为对照组508例、60～89 ml/(min·173m^2)组(A组)403例、30～59 ml/(min·173 m^2)组(B组)221例、1 5～29 ml/(min·1 73 m^2)组(C组)104例和<15ml/(min·1 73 m^2)组(D组)28例。采用logistic回归分析肾功能与冠心病之间的关系。结果与对照组比较,C组和D组患者冠心病患病率明显升高,差异有统计学意义(P<0.05,P<0.01);且男性较女性冠心病患病率明显升高,差异有统计学意义(P<0.05,P<0.01)。logistic回归分析显示,调整影响冠心病危险因素后,冠心病风险仍随eGFR的降低而增加(P=0.00)。结论年龄>65岁老年患者肾功能损害是其患冠心病的一个独立危险因素。
Objective To study the relation between kidney function damage and coronary artery disease（CAD） in the elderly. Methods 1264 patients above 65 years old were divided into five groups according to estimated glomerular filtration rate[eGFR： ml/（min · 173 m2 ）] ： ≥90,60 - 89,30-59,15-29 and 〈15. Taking the eGFR≥90 ml/（min · 173 m2） as the control baseline to analyse the relationship between kidney function and CAD using the logistic regression model. Results The incidences of CAD in four groups （ 〈15 ,15 - 29 , 30 - 59 , 60 - 89 ） were 82. 1%, 46.2% ,21.7% and 24.6% ,respectively. The incidence in all groups was higher than that in the control group （P % 0.05） and increased with decrease in eGFR. The incidence of CAD was significantly higher in men than in women （P 〈 0.05,P 〈 0.01）. After adjusting for other risk factors of CAD,logistic regression analysis showed that the risk of CAD still increased with decrease in eGFR,theOR value was 1. 863 and 1. 912 while the eGFR was 15-29 ml/（min. 173 m2） and 15 ml/（min · 173 m2） respectively. Conclusion The kidney function damage in patients above 65 years old is an independent risk factor for CAD.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2011年第8期711-713,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
扬州市社会发展基金(YZ2007055)
