摘要
目的分析肾小球滤过率(GFR)公式估算值(eGFR)与99锝-二乙烯三胺五醋酸(99mTc-DTPA)法测定值(99mTc-GFR)的相关性,探讨适合中国慢性肾脏病(CKD)住院患者eGFR的估算方法。方法选择1033例慢性肾脏病住院患者作为研究对象,99mTc-DTPA肾动态显像法测定99mTc-GFR,酶法检测血清肌酐(SCr)水平。采用Cockcroft-Gault公式、肾脏病膳食改良试验(MDRD)公式、简化MDRD公式、中国MDRD公式、中国简化MDRD公式及CKD-EPI公式计算并用体表面积(BSA)校正后得到eGFR,分别以C-GGFR、7GFR、aGFR、c-7GFR4、c-aGFR4和CKD-EPI-GFR表示。分析99mTc-GFR与eGFR的相关性。结果相关回归分析显示,C-GGFR、7GFR、aGFR、c-7GFR4、c-aGFR4和CKD-EPI-GFR与99mTc-GFR的相关系数(r)分别为0.805、0.797、0.783、0.791、0.777和0.800,与99mTc-GFR偏差值均值分别为-2.46、-14.24、-16.53、-20.92、-22.92和-13.56。患者99mTc-GFR与SCr水平呈近似双曲线的关系。结论在基于SCr的公式估算得到的eGFR中,C-GGFR与99mTc-GFR的相关程度最高。提示当以酶法SCr测定结果作为数据源时,C-G公式较适合中国CKD住院患者eGFR的估算。
Objective To analyse the relationship between estimated glomerular filtration rate （eGFR） and 99mTc-glomerular filtration rate （99mTc-GFR）,and explore the suitable methods for eGFR of Chinese inpatients with chronic kidney disease （CKD）.Methods One thousand and thirty-three inpatients with CKD were selected,99mTc-GFR was measured by 99mTc-diethylenetriaminepentaacetic acid （99mTc-DTPA） dynamic renal imaging,and serum creatinine （SCr） was determined by enzymatic method.Cockcroft-Gault formula,modification of diet in renal disease （MDRD） equation,abbreviated MDRD equation,MDRD equation for Chinese,abbreviated MDRD equation for Chinese and CKD-EPI equation were employed for calculation and body surface area （BSA） was used for correction of eGFR （C-G GFR,7GFR,aGFR,c-7GFR4,c-aGFR4 and CKD-EPI-GFR,respectively）.The relationship between 99mTc-GFR and eGFR was analysed.Results Correlation regression analysis revealed that the correlation coefficients between C-G GFR,7GFR,aGFR,c-7GFR4,c-aGFR4,CKD-EPI-GFR and 99mTc-GFR were 0.805,0.797,0.783,0.791,0.777 and 0.800,respectively,and the differences were-2.46,-14.24,-16.53,-20.92,-22.92 and-13.56,respectively.There was approximate hyperbolic relation between 99mTc-GFR and SCr.Conclusion C-G GFR is most closely related to 99mTc-GFR among eGFR from SCr,C-G formula may be a suitable method for eGFR of Chinese inpatients with CKD when SCr is measured by enzymatic method.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第11期1376-1379,共4页
Journal of Shanghai Jiao tong University:Medical Science
