摘要
脑外伤炎性反应在继发性脑损害中起重要作用。细胞因子作为体内重要的炎性介质,参与多种病理生理过程,在脑损伤后的炎症级联反应中起着重要的作用。核因子κB(NFκ-B)、肿瘤坏死因子α(TNFα-)、可溶性细胞间黏附分子1、血管内皮黏附分子1和白细胞介素1β(IL-1β)、IL-6、IL-8、IL-16等是几种主要的促炎性细胞因子,IL-2、IL-4、IL-10、IL-13等是抗炎性细胞因子,两类细胞因子参与了脑创伤后的继发性脑损伤及损伤修复。
Inflammatory reactions plays an important role in secondary traumatic brain injury（TBI）.Being important inflammatory mediators,cytokines participate in many pathophysiologic processes and have significant function in inflammatory cascade reactions.NF-κB,TNF-α,sICAM-1,VCAM-1and IL-1β,IL-6,IL-8,IL-16 and so on are main proinflammatory cytokines,IL-2,IL-4,IL-10,IL-13and so on are antiinflammatory factors,both of which participate in nerve cell repair after TBI and protect brain tissues effectively.
出处
《医学综述》
2011年第11期1621-1624,共4页
Medical Recapitulate
关键词
脑外伤
炎性细胞因子
脑损害
Traumatic brain injury
Inflammatory cytokines
Brain damage
