摘要
目的:探讨血清胱抑素C、血肌酐、尿素氮及尿微量白蛋白在糖尿病肾病早期诊断的意义。方法:对117例2型糖尿病患者根据HbA1c的不同分为三组,50例健康体检者为对照组,采用酶法分别检测Scr和BUN水平,采用免疫比浊法分别检测CysC和U-mALB水平。结果:糖尿病C组患者Scr高于对照组;B、C组患者BUN高于对照组;A、B、C组患者CysC高于对照组,以上差别均有统计学意义(P<0.05)。C组患者CysC与U-mALB水平呈正相关,差别有统计学意义(P<0.05)。结论:CysC、Scr、BUN与U-mALB联合检测对糖尿病早期肾损伤诊断有重要意义,CysC对于诊断早期糖尿病肾病的敏感性高。
Objective：To investigate the clinical significanse of serum cystatin C,serum creatinine,blood Urea nitrogen and microalbuminuira in diagnosing diabetic nephropathy.Methods： A total of 117 patients diagnosed with type 2 diabetes separated into 3 groups by the diffierent levels of HbA1c.These groups had serum creatinine and blood Urea nitrogen measured with ankyrin method,cystatin C and microalbuminuira measured with turbidimetry method.Results： The level of serum creatinine in diabetic group C was significantly higher than that in control group（P〈0.05）.The levels of blood Urea nitrogen in diabetic group B and group C were significantly higher than those in control group（P〈0.05）.The levels of cystatin C in all of diabetic groups were significantly higher than those in control group（P〈0.05）.The serum cystatin C level had significantly positive correlation with microalbuminuira in diabetic group C（P〈0.05）.Conclusion： Co-detection of cystatin C,serum creatinine,blood Urea nitrogen and microalbuminuira has important significance to early diagnosis of DM nephropathy.CysC is a sensitive maker for renal impairment in patients with diabetic nephropathy.
出处
《中国卫生检验杂志》
CAS
2011年第5期1209-1210,共2页
Chinese Journal of Health Laboratory Technology
关键词
糖尿病肾病
血清胱抑素C
血肌酐
尿素氮
尿微量白蛋白
Diabetic Nephropathy
Cystatin C
Serum Creatinine
Blood Urea Nitrogen
Microalbuminuira
