摘要
目的探讨糖尿病肾病（DN）患者血清结缔组织生长因子（CTGF）、胱抑素C（CysC）浓度的变化及其意义。方法将82例DN患者根据尿微量白蛋白排泄率（UAER）分为正常白蛋白尿组（1组）、微量白蛋白尿组（2组）和大量白蛋白尿组（3组），分别检测各组患者血清CTGF、CysC浓度及临床生化指标，并与20例正常对照组进行比较。结果DN各组患者血清CTGF、CysC浓度显著高于对照组[CTGF：（87．65±6．09）、（105．36±7．78）、（129．05±5．12）ng／L与（68．29±5．90）ng／L，CysC：（O．99±0．10）、（1．59±0．14）、（2．53±0．27）mg／L与（0．82±0．56）mg／L，P均〈0．05]；血清CTGF、CysC浓度与UAER正相关（r=0．80、0．21，P均〈0．05）；血清CTGF、CysC与肾小球滤过率（eGFR）负相关（r=-0．85、-0．88，P均〈0．01）。结论血清CTGF、CysC浓度可以作为诊断早期DN的敏感指标，有助于评价DN的病变程度。
Objective To investigate the serum concentrations of connective tissue growth factor（CTGF） and serum cystatin C（CysC） in diabetic nephropathy（DN）patients and its clinical significance. Methods 82 cases of diabetic nephropathy patients were divided into three groups by urinary albumin excretion rate（UAER） ：normal albuminuric group（ group 1 ）, microalbuminuric group（ group 2）, macroalbuminuric group（ group 3 ）. Serum concentrations of CTGF and CysC were determined by ELISA,which was compared with 20 cases of control group. Results CTGF and CysC were markedly higher in the three groups than that in healthy controls [ CTGF： （ 87.65 ± 6.09 ）, （ 105.36 ± 7.78 ）, （ 129.05 ± 5. 12） ng/L and （68.29 ± 5.90 ） ng/L; CysC ： （0.99 ± 0. 10）, （ 1.59 ± 0. 14 ）, （2.53 ± 0.27） mg/L and （ 0. 82 ± 0. 56 ） mg/L, P 〈 0.05 ]. CTGF, CysC were all positively correlated with UAER （ r = 0.80,0.21 ,P 〈 0.05 ）, all negatively correlated with glomerular filtration rate （eGFR） （ r = - 0. 85, - 0.88, P 〈 0.01 ）. Conclusions The serum concentrations of CTGF and CysC may be early markers in predicting diabetic nephropathy and assessing its severity.
出处
《中国综合临床》
2009年第11期1164-1166,共3页
Clinical Medicine of China
关键词
结缔组织生长因子
胱抑素C
糖尿病肾病
肾小球滤过率
Connective tissue growth factor
Serum cystatin C
Diabetic nephropathy
Glomerular illtration rate
