摘要
目的:探讨KLF6和WWOX蛋白在结直肠癌组织中的表达及其临床病理意义.方法:采用免疫组织化学法分别检测40例结直肠癌及40例正常结直肠黏膜组织中KLF6和WWOX蛋白的表达,并分析两者的表达水平与其临床病理因素的关系.结果:结直肠癌组织中的KLF6和WWOX蛋白的阳性表达率明显低于正常结直肠黏膜组织(45.0%vs82.5%;37.5%vs90.0%,均P<0.05),KLF6和WWOX蛋白在结直肠癌组织中的表达呈正相关(r=0.320,P<0.05),并与肿瘤组织的分化程度、淋巴结转移及浸润深度均密切相关(均P<0.05).结论:KLF6和WWOX的低表达可能与结直肠癌的发生、发展及预后有关,联合检测两者对结直肠癌的诊断及预后判断具有重要意义.
AIM：To investigate the expression of Kruppellike factor 6（KLF6） and WW domain-containing oxidoreductase（WWOX） proteins in colorectal carcinoma and to analyze their clinicopathological signif icance.METHODS：The expression of KLF6 and WWOX proteins was detected by immunohistochemistry in 40 colorectal carcinoma specimens and 40 normal colorectal mucosa specimens.RESULTS：The positive rates of KLF6 and WWOX protein expression differed significantly between colorectal carcinoma and normal colorectal mucosa（KLF6：45.0% vs 82.5%,WWOX：37.5% vs 90.0%,both P 0.05）.The expression of KLF6 and WWOX proteins was found to be associated with tumor differentiation,lymph node metastasis,and tumor invasion in colorectal carcinoma（all P 0.05）.A positive correlation was noted between the expression of KLF6 and that of WWOX in colorectal carcinoma（r = 0.320,P 0.05）.CONCLUSION：Reduced expression of KLF6 and WWOX proteins may be related with the development,progression,and prognosis of colorectal carcinoma.Combined detection of KLF6 and WWOX protein expression is helpful for diagnosis and evaluation of the prognosis of colorectal carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第6期602-607,共6页
World Chinese Journal of Digestology
