摘要
用Ｙ－迷宫反应观察长期饮用不同浓度的氟化钠溶液对小鼠学习记忆行为的影响，然后用电镜和计算机图像分析仪观测小鼠脑内海马ＣＡ３区ＧｒａｙⅠ突触结构的损伤效应。结果表明：饮用高浓度氟化钠溶液能显著降低小鼠的学习能力，并能引起小鼠海马ＣＡ３区突触后致密物质厚度极显著减小，和引起突触间隙宽度极显著变大等超微结构的变化。结果提示，慢性氟中毒对小鼠的学习能力的显著影响可能与其脑内突触界面结构的病理变化有关。
The learning memory behavior was tested in mice on a Y maze after drinking different concentration of sodium fluoride. The impairment on the structure of Gray Ⅰ synaptic interface in the CA 3 area of mice hippocampus were quantitatively analyzed by electron microscopy and computer image processing appliance. The main results are as follows:the learning ability of mice drinking high concentration of fluoride presented remarkable deterioration,the thickness of post synaptic density (PSD) was decreased, and the width of synaptic cleft was remarkably increased. The results suggested that the impairment on the learning capability induced by fluorosis may be closely related with the pathological changes of synaptic structure in the brain of mice.
出处
《卫生研究》
CAS
CSCD
北大核心
1999年第4期210-212,共3页
Journal of Hygiene Research
基金
浙江省大型测试基金
关键词
氟中毒
学习记忆
海马
电镜
突触结构
fluoride,ultrastructure,learning memory capability,hippocampus,synaptic structure
