摘要
用Y-迷宫和一次性被动回避反应模型，对不同月龄小鼠的学习记忆行为进行了动态观察，同时定量分析了青年、中年和老年小鼠海马CA3区和皮层感觉运动区的突触结构参数。结果表明，随着月龄的增长，观察到以下变化：（1）分辨学习及记忆保持力显著下降；（2）两脑区突触界面曲率和间隙宽度加大和变宽，突触后致密物质变薄。此外，穿孔性突触和三种弯曲型突触比例也有不同程度的变化。结果提示，衰老过程中，小鼠学习记忆行为与其脑内突触结构参数变化密切相关。
In this study, the abilities of spontaneous behavior, learning and memory of mice during natural aging were investigat ed using one-trial passive avoidance task and Y-maze. The synaptic structural parameters were quantitatively analysed mainly in two cerebral areas (hippocampal CA3 and sensori-motor areas of cerebral cortex) in three groups (young, mid-age and old). The main results are as follows: (1) The abilities of discrimination learning and memory retention was decreased significantly. (2)The curvature of synaptic interface and width of synaptic cleft were remarkably increased, while the thickness of postsynaptic density (PSD) was reduced. In the meantime, the occurrence of perforated synapse and percentage of different types of synaptic curvature were also changed in the two brain areas mentioned above. These results suggest that the alterations of learning and memory behavior are closely associated with that of synaptic structural parameters of brain in natural aging mice.
出处
《神经解剖学杂志》
CAS
CSCD
北大核心
1998年第2期147-151,共5页
Chinese Journal of Neuroanatomy
基金
国家自然科学基金
关键词
衰老
学习记忆
突触结构参数
电镜
小鼠
aging, learning-memory, synaptic structural parameters, electron microscopy, mice
