摘要
[目的]探讨稀土元素钐的长期摄入对小鼠学习记忆能力及脑内微量元素含量的影响。[方法]通过在饮水中加入硝酸钐(0、5、50、500和2000mg／L)使小白鼠染毒,3个月后用Y-迷宫测定学习记忆能力;用电感耦合等离子体原子发射法(ICP-AES)测定脑内微量元素Ca、Cu、Mg、Mn、Ni、Fe、Zn的含量。[结果]硝酸钐染毒后,小鼠达到学会标准所需训练次数增加,记忆保持率下降;脑内Ca、Mn、Cu、Mg的含量增加,而Fe、zn、Ni的含量下降。[结论]钐的长期摄入对脑功能有明显的损伤作用,影响脑内微量元素的吸收、分布和平衡。
[ Objective ] To study the effects of the long-term intake of samarium on learning and memory of mice and content of trace element in brain of mice. [ Methods ] The mice were fed with different concentration（ 0, 5, 50, 500, 2000mg/L ）of Sm （ NO3 ）3 for three months, then their learning and memory ability were measured using Y-maze. The level of trace elements such as Ca, Cu, Mg, Mn, Ni, Fe and Zn in brain of mice were measured by ICP-AES. [ Results ] Compared with control group, there was significant decreasing in learning and memory ability in the groups of low and high concentrations of Sin（ NO3 ）3 · The level of Ca, Cu, Mg and Mn in brain of mice increased significantly, while the level of Fe, Zn and Ni decreased. [ Conclusion ] Longterm intake of samarium has remarkable damage on mice brain-function and has certain effect on the metabolism and distribution of some trace elements in brain, which may affect their physiological function.
出处
《环境与职业医学》
CAS
北大核心
2007年第2期193-195,共3页
Journal of Environmental and Occupational Medicine
关键词
稀土
学习
记忆
微量元素
rare earth
learning
memory
trace element
