摘要
目的探讨survivin、bax及caspase-3的表达与稽留流产的关系。方法以35例稽留流产病人为病例组,30例正常妊娠者为对照组。采用免疫组织化学SP法检测绒毛细胞滋养细胞和合体滋养细胞及蜕膜组织蜕膜细胞中survivin、bax和caspase-3的表达。结果病例组妊娠组织中survivin的表达明显低于对照组,bax及caspase-3的表达明显高于对照组(uc=2.87～5.29,P<0.01)。病例组survivin与bax及caspase-3的表达均呈负相关(r=-0.59、-0.71,P<0.05、0.01),bax与caspase-3的表达呈正相关(r=0.79,P<0.01)。结论 survivin的低表达、bax及caspase-3的高表达在稽留流产的发生中起重要作用。
Objective To study the relationship of expressions of survivin,bax and caspase-3 with missed abortion.Methods Thirty-five missed abortion patients were assigned as study group,and 30 with normal pregnancy as controls.Immunohistochemistry technique was employed to detect the expressions of survivin,bax and caspase-3 in cytotrophoblast and syncytiotrophoblast of villi and decidual cells of decidua. Results Compared with that of the controls,the expression of survivin in the study group was significantly lower,while the expressions of bax and caspase-3 were higher（uc=2.87-5.29,P0.01）.In thestudy group,the survivin expression was negatively correlated with the expressions of bax and caspase-3（r=-0.59,0.71;P0.05,0.01）,respectively,and the expression of bax was found to be positively correlated with caspase-3（r=0.79,P0.01）. Conclusion Low expression of survivin and high expressions of bax and caspase-3 play an important role in the occurrence of missedabortion.
出处
《齐鲁医学杂志》
2011年第2期165-166,168,共3页
Medical Journal of Qilu
