摘要
目的分析正常早孕妇女和稽留流产患者绒毛及蜕膜组织中survivin和Fas蛋白的表达及意义。方法用免疫组化法检测正常早孕妇女和稽留流产患者绒毛和蜕膜组织中survivin和Fas蛋白的表达。结果 Survivin表达早孕组绒毛显著高于稽留流产组绒毛(P<0.05),但早孕组蜕膜与稽留流产组相比无显著性差异(P>0.05),早孕绒毛组织Survivin的最大阳性强度显著高于蜕膜组织(P<0.05)。Fas蛋白表达稽留流产组蜕膜显著高于绒毛及早孕蜕膜(P<0.05)。结论Survivin和Fas蛋白在稽留流产过程中可能发挥重要作用。
Objective：To study the expressions of Survivin and Fas proteins in human chorionic villus and decidual tissue during missed abortion.Methods：The immunohistochemistry method was used to study the distribution and changes of the survivin and Fas proteins in the cells of human chorionic villus and deciduas tissue. Results：The expression of Survivin of chorionic villus in normal pregnancy group increased significantly compared with that in missed abortion group（P〈0.05）but The expression of Survivin of decidual tissue in normal pregnancy group not difference compared with that in missed abortion group（P〉0.05）,The maximum positive degree of Survivin in chorionic villus increased significantly compared with that in decidual tissue in normal pregnancy group（P〈0.05）.in missed abortion,the expression of Fas proteins in decidual tissue was higher significantly compared with that in chorionic villus and decidual tissue of normal pregnancy group（P〈0.05））Conclusion：Survivin and Fas proteins play an important role during missed abortion.
出处
《中国优生与遗传杂志》
2015年第12期47-48,77,共3页
Chinese Journal of Birth Health & Heredity
基金
兰州市科技局医疗卫生类科技支撑计划
编号:201201
