摘要
目的:研究肉毒碱棕榈酰转移酶Ⅱ(Carnitine Palmitoyltransferase Ⅱ,CPT Ⅱ)基因F352C多态性与日本高知地区非酒精性脂肪性肝炎(NASH)易感性的相关性。方法:提取日本高知地区45例肝活检证实的NASH患者和148例健康志愿者的外周静脉血,应用聚合酶链式反应(PCR)进行检测分析。结果:NASH组中A等位基因的频率显著高于正常对照组(P<0.01);NASH组中A/-基因型的频率显著高于正常对照组(P<0.01)。结论:CPT Ⅱ基因F352C多态性与NASH发生发展有显著相关性。
Objective：To investigate whether the carriers of F352C variant impaired in Carnitine Palmitoyltransferase Ⅱ（CPT Ⅱ）activity are more susceptible to nonalcoholic steatohepatitis（NASH） in Japanese Kochi area.Methods：Blood samples of 45 patients with biopsy-proven NASH and 148 healthy volunteers were analyzed by PCR.Results：F352C variant allele of the CPT Ⅱ gene was significantly more frequent in NASH patients than in healthy volunteers（P〈0.01）,and carriers of F352C variant were significantly more frequent in NASH patients than in healthy volunteers（P〈0.01）.Conclusion：F352C variant of CPT Ⅱ could be a candidate molecule that determines the susceptibility to NASH.
出处
《黑龙江医药科学》
2011年第1期6-7,共2页
Heilongjiang Medicine and Pharmacy
