摘要
目的:观察CD44V6和MMP-9在舌癌(tongue squarnous cell carcinomas,TSCC)组织中的表达及其与临床病理因素和预后的关系。方法:采用免疫组织化学PV9000法检测60例舌癌、21例转移淋巴结及15例癌旁正常组织中CD44V6和MMP-9的表达。结果:CD44V6在舌癌中的阳性表达率略低于癌旁组织,无显著意义;MMP-9在舌癌中的阳性表达率明显高于癌旁正常组织(P<0.05),并与舌癌的组织学分级呈正相关(P<0.05);在有颈淋巴结转移组中的舌癌组织CD44V6和MMP-9阳性表达率明显高于无颈淋巴结转移组(P<0.05);舌癌中CD44V6和MMP-9表达强阳性者有4例复发(5年内)。结论:CD44V6和MMP-9在舌癌组织中的表达与颈淋巴结转移密切相关,可作为评价舌癌颈淋巴结转移和预后的生物学指标。
Objective：To detect the expression of CD44v6/MMP-9in tongue squamous cell carcinomas.Methods：Immunohistochemical method（PV9000）was applied to examine the expression of CD44v6 and MMP-9 in 60 tongue squamous cell carcinoma,21 cervical lymph node metastasis and 15 normal tissue beside TSCC.Results：The expression of CD44v6 in TSCC was little lower than that in non-cancerous tissues,no significance.MMP-9 expression grade was significantly higher in TSCC than that in normal oral mucosa（P〈0.05）.MMP-9with cervical lymphnode metastasis had higher expression than that of without lymph node metastasis（P〈0.05）.Expression of CD44v6 and MMP-9 was positively correlated to the classify of tumor cells（P〈0.05）.Strong positive expression of CD44v6 and MMP-9 in tongue had 4cases of recurrence（in 5years）.Conclusion：The expressions of CD44V6 and MMP-9in TSCC is closely related to cervical lymph node metastasis,and it can be used as biological indicators to value TSCC cervical lymph node metastasis and prognosis.
出处
《口腔医学研究》
CAS
CSCD
北大核心
2010年第5期740-743,共4页
Journal of Oral Science Research
