摘要
目的:分析铜绿假单胞菌的临床分布特点及药物耐药性,为临床预防控制院内感染及治疗提供依据。方法:研究对象为2009年1月-2010年1月临床分离的189株铜绿假单胞菌,分别对其感染状况、临床分布及耐药性进行研究分析。结果:189株铜绿假单胞菌主要分离自痰液,占51.3%;其次为创面分泌物、脓液、尿液、咽拭子、血液,分别占13.2%、11.6%、10.1%、6.3%、4.8%。医院感染铜绿假单胞菌主要分布于ICU病房,占36.0%,其次为呼吸内科、肿瘤科、烧伤科、泌尿外科、骨科和普外科,分别占25.9%、13.8%、9.0%、7.9%、4.8%和2.6%。铜绿假单胞菌对氨苄西林、头孢唑啉、头孢西丁、头孢孟多的耐药性均较高,耐药率均达90%以上;对头孢塞肟、头孢哌酮、头孢曲松、头孢他啶、氨曲南、阿米卡星、环丙沙星的耐药率分别为57.1%、38.6%、32.8%、31.2%、25.4%、28.6%和18.5%。对亚胺培南最敏感,耐药率仅为12.2%。结论:铜绿假单胞菌是临床较常见的病原菌,其耐药现象较为严重,应引起临床重视。
Objective：To investigate clinical distribution and drug sensitivity of Pseudomonas aeruginosa.Methods：From January 2009 to January 2010, 189 strains of Pseudomonas aeruginosa were retrospectively analyzed for their clinical distribution, status of infection and drug resistance.Results：Pseudomonas aeruginosa separated from sputum specimens were predominant, next was wound surface secretion （13.2%）, liquor puris （11.6%）, urine （10.1%）, throat swab （6.3%） and blood （4.8%）.Pseudomonas aeruginosa was mainly distributed in ICU（36.0%）, next was respiration internal medicine（25.9%）, tumor department（13.8%）, empyrosis department（9.0%）, urinary surgery（7.9%）, orthopedics（4.8%）and common surgery（2.6%）.The results of drug sensitivity tests showed drug resistance rate of Pseudomonas aeruginosa was over 90% to penicillins, cefazolin, cefoxitin and cefamandole.The drug resistance rate to cefoperazone, ceftriaxone, ceftazidime, aztreonam, amikacin and ciprofloxacin was 57.1%, 38.6%, 32.8%, 31.2%, 25.4%, 28.6% and 18.5%.The most sensitive to imipenem （12.2% ）.Conclusion：Pseudomonas aeruginosa was major pathoge in our hospital and its drug resistance was severe, which should cause the clinical reconstruction.
出处
《亚太传统医药》
2010年第9期174-176,共3页
Asia-Pacific Traditional Medicine
关键词
铜绿假单胞菌
临床分布
耐药性
Pseudomonas Aeruginosa
Clinical Distribution
Drug Resistance
