摘要
目的探讨引起医院感染的铜绿假单胞菌的临床分布及其药敏结果分析,为临床预防控制院内感染及治疗提供直接可靠的参考依据。方法中山大学附属第五医院2007年9月至2008年8月分离培养出318株铜绿假单胞菌,分别对其临床感染状况、分布、细菌药敏情况进行回顾性分析。结果铜绿假单胞菌从痰标本中分离的菌株最多(70.4%),其次是伤口分泌物(12.6%)及中段尿液(9.4%),也是中山大学附属第五医院近年来阳性标本中分离率最高的一种细菌(15.7%)。重症监护病房(ICU)、呼吸内科为院内感染铜绿假单胞菌的高发病区。临床上对该菌比较敏感的抗生素分别为多黏菌素E(92.1%)、美诺培南(89.3%)、亚胺培南(84.2%)、哌拉西林/三唑巴坦(69.2%);耐药性最高是氨苄西林/舒巴坦(90.6%)。结论通过对菌株分布及药敏结果的分析,提示临床对医院感染铜绿假单胞菌的现象应高度重视。通过建立、健全预防院内感染相关制度,加强院内感染监测机制等措施,减少院内感染的发生。对已发生的院内感染,应加强细菌的药敏监测,选择敏感性强的药物,避免广谱抗生素的长期应用,降低菌株的耐药性,减少临床抗生素的选择压力。
Objective To investiqate the clinical distribution and drug sensitivity of Pseudomonas aeruginosa which leads to hospital infection results for clinical treatment and prevention of nosocomial infection,so as to provide direct and reliable reference. Methods A total of 318 strains isolated Pseudomonas aeruginosa from September 2007 to August 2008, were reviewed for their clinical distribution status of infection, the antibiotic resistance and the usage of antibiotics. Results Pseudomonas aeruginosa isolates separated from sputum specimens were predominant（70.4%）, wound secretions（12.6 % ） and urine（9.4%）, but for our positive samples isolated in recent years, the highest isolation rate of bacterium（15.7%）. Its high incidence was in ICU and respiratory department. The more sensitive antibiotics were polymyxin E（92.1 % ）, meraopenem（89.3 %）, imipenem （84.2%）, piperaeillin/tazobactam （ 69.2%）.The highest resistant rate to ampicillin/sulbactam was 90.6 %. Conclusion The analysis of the distribution and drug sensitivity of strains suggests that the phenomenon of nosocomial infection by Pseudomonas ceruginosa in hospital should be taken very seriously, to construct a system related to the prevention of nosocomial infection and strengthen its supervision,strict aseptic operation and other measures can reduce the incidence of nosocomial infections. If nosocomial infections occurr, the supervision on sensitivity of bacterium and the drug sensitivity in hospital should be strengthened. In order to reduce the stress of selecting antibiotics,it is necessary to choose a high-sensitive medicine and avoid the long-term administration of the broad spectrum antibiotics
出处
《检验医学与临床》
CAS
2009年第9期673-674,676,共3页
Laboratory Medicine and Clinic
关键词
铜绿假单胞菌
临床分布
药敏试验
pseudomonas aeruginosa
clinical distribution
drug sensitivity test
