摘要
目的探讨碱性成纤维细胞生长因子I型受体(FGFR1)在尖锐湿疣(CA)中的表达及其临床意义。方法应用免疫组化SP法分别检测FGFR1在33例尖锐湿疣和10例正常人皮肤组织中的表达情况。结果正常对照包皮组织中FGFR1无或仅有弱的表达,CA皮损组织则呈强阳性表达,两组间比较有极显著统计学意义(P<0.001)。结论 FGFR1在尖锐湿疣组织中过度表达,提示其可能在促真皮毛细血管生成和表皮细胞增殖中发挥重要作用。
Aim To investigate the expression and clinical significance of basic fibroblastic growth factor recepter 1（FGFR1）in condylomata acuminatum（CA）patients.Methods The expression of FGFR1 in 33 CA specimens and 10 normal human skins were analyzed by SP immunohistochemistry.Results There were no or weak expressions of FGFR1 in the stratum basale and stratum spinosum of foreskin from normal controls,while strong expressions of FGFR1 in the lesional skin of CA were observed,showing significant differences between the two groups（P 0.01）.Conclusions Over expression of FGFR1 may promote new blood vessel formation and epidermal cell over proliferation and may involve in the pathogenesis of CA.
出处
《中国热带医学》
CAS
2010年第9期1101-1102,共2页
China Tropical Medicine
基金
海南省自然科学基金(30864)
关键词
成纤维细胞生长因子I型受体
尖锐湿疣
免疫组织化学
Basic fibroblastic growth factor recepter 1
Condylomata acuminatum
Immunohistochemistry
